ArticleACS omega2026
Fabrication and Optimization of a Polycaprolactone-Based Ductular Blood-Brain Barrier Model Using an Electrospinning Technique.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Central nervous system (CNS) disorders are the primary cause of the global health burden. Nevertheless, novel therapies approved for these disorders are among the fewest compared with their counterparts. The absence of effective, reliable in vitro blood-brain barrier (BBB) models that mimic in vivo barrier properties hinders the discovery of therapies for CNS diseases. This work introduces a three-dimensional (3D) system that uses a polycaprolactone (PCL) ductular scaffold to most closely mimic the structure of blood-brain capillaries. The duct was prepared via electrospinning, optimized, and characterized for fiber structure and mechanical strength. Furthermore, the designed duct was seeded with endothelial cells (ECV-304) to assess their ability to proliferate and grow within the ductal fiber. Finally, barrier integrity was evaluated by an immunofluorescence assay and transepithelial/transendothelial electrical resistance (TEER) measurements. The optimized duct displayed Beadles' fiber with a high Young's modulus value (34.7 ± 3.59 MPa), reflecting its good mechanical strength. Besides, ECVs-304 could cover 85.36 ± 14.36% of the duct surface after 14 days of seeding. The results showed that seeding the duct with a high cell density (20 × 10
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