Evidence map›Paper›PMID 42598049›Full record

ArticleMaterials today. Bio2026

Photo-triggered NO combined with photobiomodulation promotes endothelial repair after balloon angioplasty.

Shu-Jie Jin, Chen-Ze Deng, Rou-Ye Wang, Fan Jia, Pei-Hong Ji, Ya Peng, Ke-Feng Ren, Jian-Min Liu, You-Xiang Wang, Jian Ji

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shu-Jie JinMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Shaoxing Institute, Zhejiang University, Hangzhou, 310058, China.
Chen-Ze DengMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Shaoxing Institute, Zhejiang University, Hangzhou, 310058, China.
Rou-Ye WangMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Shaoxing Institute, Zhejiang University, Hangzhou, 310058, China.
Fan JiaKey Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, China.
Pei-Hong JiHangzhou Matrix Medical Technology Co. Ltd, Hangzhou, 311100, China.
Ya PengNeurosurgery Department of the Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
Ke-Feng RenMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Shaoxing Institute, Zhejiang University, Hangzhou, 310058, China.
Jian-Min LiuNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
You-Xiang WangMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Shaoxing Institute, Zhejiang University, Hangzhou, 310058, China.
Jian JiMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Shaoxing Institute, Zhejiang University, Hangzhou, 310058, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Balloon angioplasty, though effective for vascular stenosis, inevitably induces endothelial injury during dilation and clinical strategies to actively promote intimal repair remain lacking. Photobiomodulation (PBM) has demonstrated promising effects in tissue repair through its potent biological regulatory functions. Meanwhile, light is also a particularly appealing tool for drug delivery due to its strong spatiotemporal controllability. In this study, we developed a red light-triggered nitric oxide (NO) releasing coating based on the photosensitive NO donor S-Nitroso-N-acetyl-DL-penicillamine (SNAP). The coating enabled on-demand NO release under red light irradiation, modulating cellular signaling pathways to guide functional endothelial repair. After releasing NO, the SNAP coating significantly promoted endothelial cell (EC) migration and proliferation, while suppressing smooth muscle cell (SMC) activity, resulting in an increase in the EC/SMC ratio by 0.48 in co-culture. In vivo experiments, the combined effect of PBM and light-controlled drug release alleviated vascular inflammation and reduced restenosis (intimal hyperplasia decreased by 63 μm), demonstrating superior therapeutic efficacy compared to PBM alone.

Indexed as

Balloon angioplastyEndothelial repairNitric oxidePhotobiomodulationPhoto-triggered drug release

Identifiers

PMID42598049
PMCPMC13470320

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.