Evidence map›Paper›PMID 42598052›Full record

ArticleJournal of pharmaceutical analysis2026

Rapid and sensitive screening of carbonic anhydrase natural inhibitors in traditional Chinese medicine via a carbon quantum dot-affinity adsorption nanosystem.

Lingling Yang, Shuxian Zhang, Xiaoxuan Fan, Keshuai Liu, Rui Mai, Wangyan Zhao, Qiang Han, Yongjian Ai, Qionglin Liang, Xueqin Ma and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lingling YangKey Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, College of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.
Shuxian ZhangKey Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, College of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.
Xiaoxuan FanKey Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, College of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.
Keshuai LiuKey Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, College of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.
Rui MaiKey Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, College of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.
Wangyan ZhaoKey Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, College of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.
Qiang HanDepartment of Chemistry, Tsinghua University, Beijing, 100084, China.
Yongjian AiMOE Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100193, China.
Qionglin LiangDepartment of Chemistry, Tsinghua University, Beijing, 100084, China.
Xueqin MaKey Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, College of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.
Guoning ChenKey Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, College of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The advancement of carbonic anhydrase (CA) activity and its inhibitor assays is crucial for drug development. Screening effective components from complex traditional Chinese medicine (TCM) systems as inhibitors is an important step in drug development. However, developing a simple and rapid method for this purpose remains challenging. Herein, a fluorescence (FL) sensing probe based on carbon quantum dots (CDs) integrated with a target affinity identification model for sensitive and specific CA detection and CA inhibitor screening was proposed. A FL sensing probe based on CDs was designed for the rapid detection of potential inhibitors in TCM samples on CA at first. Then the target affinity strategy was employed to accurately capture, isolate, and identify the active ingredient with inhibitory effects in the TCM sample. The developed method integrates two analytical models for screening CA inhibitors, significantly improving the accuracy and reproducibility of screening. The method was validated with positive, negative control and applied to screen CA inhibitors from 80 different TCM samples. The results revealed that ursolic acid and oleanolic acid from

Indexed as

Affinity adsorptionBiosensingCarbonic anhydraseCarbon quantum dotInhibitor screening

Identifiers

PMID42598052
PMCPMC13471075

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.