Evidence map›Paper›PMID 42598111›Full record

ArticleiScience2026

Dynamic functional connectivity variability may explain hypoxia-induced cognitive impairment at high-altitude.

Siyao Zeng, Sijia Guo, Yang Zhou, Jiebing He, Yang Ou, Tingting Yang, Jia Wang, Wensheng Zhai, Baojuan Li, Jie Liu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Siyao ZengThe Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environments, Shaanxi Provincial Key Laboratory of Environmental Health Hazard Assessment and Protection, Shaanxi Provincial Key Laboratory of Free Radical Biology and Medicine, Department of Occupational and Environmental Health, School of Public Health, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Sijia GuoThe Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environments, Shaanxi Provincial Key Laboratory of Environmental Health Hazard Assessment and Protection, Shaanxi Provincial Key Laboratory of Free Radical Biology and Medicine, Department of Occupational and Environmental Health, School of Public Health, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Yang ZhouThe Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environments, Shaanxi Provincial Key Laboratory of Environmental Health Hazard Assessment and Protection, Shaanxi Provincial Key Laboratory of Free Radical Biology and Medicine, Department of Occupational and Environmental Health, School of Public Health, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Jiebing HeThe Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environments, Shaanxi Provincial Key Laboratory of Environmental Health Hazard Assessment and Protection, Shaanxi Provincial Key Laboratory of Free Radical Biology and Medicine, Department of Occupational and Environmental Health, School of Public Health, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Yang OuThe Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environments, Shaanxi Provincial Key Laboratory of Environmental Health Hazard Assessment and Protection, Shaanxi Provincial Key Laboratory of Free Radical Biology and Medicine, Department of Occupational and Environmental Health, School of Public Health, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Tingting YangThe Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environments, Shaanxi Provincial Key Laboratory of Environmental Health Hazard Assessment and Protection, Shaanxi Provincial Key Laboratory of Free Radical Biology and Medicine, Department of Occupational and Environmental Health, School of Public Health, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Jia WangXijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Wensheng ZhaiSchool of Biomedical Engineering, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Baojuan LiSchool of Biomedical Engineering, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Jie LiuThe General Hospital of PLA Xizang Military Area Command, Lhasa, Xizang 850007, China.
Wenjing LuoThe Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environments, Shaanxi Provincial Key Laboratory of Environmental Health Hazard Assessment and Protection, Shaanxi Provincial Key Laboratory of Free Radical Biology and Medicine, Department of Occupational and Environmental Health, School of Public Health, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Xiaoming ChenThe Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environments, Shaanxi Provincial Key Laboratory of Environmental Health Hazard Assessment and Protection, Shaanxi Provincial Key Laboratory of Free Radical Biology and Medicine, Department of Occupational and Environmental Health, School of Public Health, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long-term exposure to a high-altitude (HA) hypoxic environment induces cognitive impairments, yet the underlying temporal mechanisms remain elusive. This longitudinal study investigated brain functional alterations associated with cognitive changes in 49 college freshmen relocated from sea level to Tibet, with comprehensive cognitive assessments and magnetic resonance imaging (MRI) at baseline and 2- and 4-year follow-ups. Resting-state fMRI quantified changes in regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF)/fractional ALFF (fALFF), static functional connectivity (sFC), and dynamic FC (dFC). Behavioral data confirmed persistent cognitive deficits, while neuroimaging analyses revealed biphasic patterns (initial suppression then partial/full recovery) in ReHo, ALFF/fALFF, and sFC. Notably, dFC variability in the right orbital middle frontal gyrus (ORBmid.R) and Heschl's gyrus (HES.R) increased at 2 years and remained elevated, with this alteration strongly correlated with cognitive changes. Our findings highlight that elevated dFC variability in two brain regions is a key contributor to chronic hypoxia-induced cognitive impairments.

Indexed as

cognitive impairmentsdynamic functional connectivityhigh altitudemagnetic resonance imaging

Identifiers

PMID42598111
PMCPMC13470281

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.