Evidence map›Paper›PMID 42598142›Full record

ArticleBioactive materials2027

A hierarchical, pH-responsive nanocomposite hydrogel platform for synergistic microenvironment reprogramming and attenuation of inflammatory periodontal bone loss.

Yixin Zhang, Xiaodong Jing, Xu Wang, Zhengchu Zhang, Jiaqi Xin, Zhengyang Chang, Yue Su, Zhimin Yan, Anhuai Lu, Hua Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yixin ZhangBeijing Key Laboratory of Mineral Environmental Function, School of Earth and Space Sciences, Peking University, Beijing, 100871, China.
Xiaodong JingBeijing National Laboratory for Molecular Sciences, Center for Soft Matter Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Xu WangNational Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Department of Oral Medicine, School and Hospital of Stomatology, Peking University, Beijing, 100871, China.
Zhengchu ZhangBeijing National Laboratory for Molecular Sciences, Center for Soft Matter Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Jiaqi XinBeijing National Laboratory for Molecular Sciences, Center for Soft Matter Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Zhengyang ChangDepartment of Orthopedics, The Fourth Medical Center, Chinese PLA General Hospital, Beijing, 100048, China.
Yue SuBeijing National Laboratory for Molecular Sciences, Center for Soft Matter Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Zhimin YanNational Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Department of Oral Medicine, School and Hospital of Stomatology, Peking University, Beijing, 100871, China.
Anhuai LuBeijing Key Laboratory of Mineral Environmental Function, School of Earth and Space Sciences, Peking University, Beijing, 100871, China.
Hua LuBeijing National Laboratory for Molecular Sciences, Center for Soft Matter Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conventional periodontitis therapies are limited by their inability to concurrently address the interconnected challenges of persistent bacterial infection, excessive oxidative stress, and immune dysregulation. To overcome this, we developed an injectable, pH-responsive nanocomposite polypeptide hydrogel, PepGel@ZnO-PLP, through rational molecular interface engineering. The system is constructed by integrating poly-L-proline (PLP)-functionalized zinc oxide nanoparticles (ZnO-PLP) into a poly-L-glutamate containing polypeptide network (PepGel) via dynamic Zn

Indexed as

Inflammatory periodontal bone lossMicroenvironment reprogrammingNanocomposite hydrogelPoly-L-proline

Identifiers

PMID42598142
PMCPMC13471225

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.