Evidence map›Paper›PMID 42598441›Full record

ArticleBioactive materials2027

Retrievable "sea-island" microstructured zwitterionic-silicone hydrogel devices: augmented oxygen transport and anti-fibrosis for sustaining islet survival.

Danyang Chen, Hongying Wang, Yipeng Tang, Jinghui Li, Xu Tian, Yudi Pang, Siyu Bao, Liping Lang, Zhuoya Wang, Haolun Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Danyang ChenSchool of Materials Science and Engineering, State Key Laboratory of Precious Metal Functional Materials, Tianjin University, Tianjin, 300350, China.
Hongying WangSchool of Materials Science and Engineering, State Key Laboratory of Precious Metal Functional Materials, Tianjin University, Tianjin, 300350, China.
Yipeng TangChest Hospital, Tianjin University, Tianjin, 300222, China.
Jinghui LiChest Hospital, Tianjin University, Tianjin, 300222, China.
Xu TianSchool of Materials Science and Engineering, State Key Laboratory of Precious Metal Functional Materials, Tianjin University, Tianjin, 300350, China.
Yudi PangSchool of Materials Science and Engineering, State Key Laboratory of Precious Metal Functional Materials, Tianjin University, Tianjin, 300350, China.
Siyu BaoSchool of Materials Science and Engineering, State Key Laboratory of Precious Metal Functional Materials, Tianjin University, Tianjin, 300350, China.
Liping LangSchool of Materials Science and Engineering, State Key Laboratory of Precious Metal Functional Materials, Tianjin University, Tianjin, 300350, China.
Zhuoya WangSchool of Materials Science and Engineering, State Key Laboratory of Precious Metal Functional Materials, Tianjin University, Tianjin, 300350, China.
Haolun WangSchool of Materials Science and Engineering, State Key Laboratory of Precious Metal Functional Materials, Tianjin University, Tianjin, 300350, China.
Qiao LiSchool of Materials Science and Engineering, State Key Laboratory of Precious Metal Functional Materials, Tianjin University, Tianjin, 300350, China.
Yongmao LiSchool of Materials Science and Engineering, State Key Laboratory of Precious Metal Functional Materials, Tianjin University, Tianjin, 300350, China.
Wenguang LiuSchool of Materials Science and Engineering, State Key Laboratory of Precious Metal Functional Materials, Tianjin University, Tianjin, 300350, China.
Jianhai YangSchool of Materials Science and Engineering, State Key Laboratory of Precious Metal Functional Materials, Tianjin University, Tianjin, 300350, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Islet encapsulation is a transformative strategy for type 1 diabetes (T1D) cellular therapy, enabling islet transplantation without lifelong immunosuppression. However, macroscale encapsulation faces prominent challenges: poor surgical retrieval, hypoxia, and foreign body response (FBR)-induced fibrosis, which severely compromise clinical translation. Herein, we develop a sea-island microstructured zwitterionic-silicone hydrogel device via copolymerization of siloxane monomer SiGMA, zwitterionic monomer carboxybetaine acrylamide (CBAA), and hydrogen-bonding monomer N-acryloyl glycinamide (NAGA). Notably, NAGA enhances hydrogel structural stability via strong H-bonds, reinforcing network and mechanical integrity to facilitate safe retrieval; importantly, NAGA's hydrogen bonding crosslinks allow the hydrogel device to be heat-sealed, preventing cell leakage and maintaining immunoisolation. The incorporation of SiGMA induces hydrophobic phase separation, generating silicone-rich polymer microdomains that enhance oxygen permeability to alleviate islet hypoxia, while zwitterionic CBAA significantly improves antifouling performance and mitigates fibrotic encapsulation by suppressing the host FBR. After 8 weeks of implantation in mice and beagle dogs, the device exhibits minimal fibrotic encapsulation and can be readily retrieved. Notably, even without pre-vascularization or immunosuppression, the transplanted islets in diabetic mice sustain normoglycemia for up to 400 days. These results demonstrate a robust retrievable encapsulation device that addresses key bottlenecks in islet transplantation, advancing its potential translation for T1D.

Indexed as

Fibrosis resistanceIslet transplantationOxygen transportSea-island microstructureZwitterionic-silicone hydrogel

Identifiers

PMID42598441
PMCPMC13471058

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.