Evidence map›Paper›PMID 42598458›Full record

ArticleJournal of pharmaceutical analysis2026

Multi-omics uncovers the critical role of ceramide-mediated

Zhichao Wang, Yan Zhang, Jinli Hou, Bingyu Lv, Xue Li, Li Gao, Xuemei Qin, Yuetao Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhichao WangModern Research Center for Traditional Chinese Medicine, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan, 030006, China.
Yan ZhangModern Research Center for Traditional Chinese Medicine, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan, 030006, China.
Jinli HouModern Research Center for Traditional Chinese Medicine, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan, 030006, China.
Bingyu LvModern Research Center for Traditional Chinese Medicine, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan, 030006, China.
Xue LiModern Research Center for Traditional Chinese Medicine, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan, 030006, China.
Li GaoModern Research Center for Traditional Chinese Medicine, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan, 030006, China.
Xuemei QinModern Research Center for Traditional Chinese Medicine, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan, 030006, China.
Yuetao LiuModern Research Center for Traditional Chinese Medicine, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan, 030006, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The epidemiology of tolerance and susceptibility in an individual suggests that aging and malnutrition (MN) should be critically regarded as a common clinical combination in the pathomechanism of pressure ulcer/injury (PU). However, the influence of these two factors on wound healing has not been fully elucidated. In this study, we used a random forest (RF) to screen macro and laboratory indicators to compare the characteristic variables of single versus dual interventions for aging or MN. The 16S ribosomal RNA (16S rRNA) microbiome sequencing as well as serum and skin metabolomics studies were conducted, along with the integration of bulk and single-cell RNA sequencing (scRNA-seq) data using bioinformatics. MetOrigin, MIMOSA2, and MetaNet were used to identify the molecular driving factors. The main findings demonstrated that the dual intervention played an essential role in inflammatory infiltration, promoting

Indexed as

AcinetobacterAgingArachidonic acidCeramideMalnutritionPressure ulcer/injury

Identifiers

PMID42598458
PMCPMC13471078

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.