Evidence map›Paper›PMID 42598466›Full record

ArticleACS omega2026

Structure-Affinity Relationship Optimization of SYA16263 Yields New Ligands with Improved Receptor Affinity and Antipsychotic-Like Properties.

Uma M Gonela, Barbara A Bricker, Chandrashekhar Voshavar, Edem K Onyameh, Matilda E Adzimah, Edith B Kuudaar, Alexus A Morgan, Ismail L Jones, Eljaye W Tellis, Seth Y Ablordeppey

Abstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Uma M GonelaDivision of Basic Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, Florida 32307, United States.
Barbara A BrickerDivision of Basic Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, Florida 32307, United States.
Chandrashekhar VoshavarDivision of Basic Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, Florida 32307, United States.ORCID https://orcid.org/0000-0003-3350-3977
Edem K OnyamehDivision of Basic Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, Florida 32307, United States.
Matilda E AdzimahDivision of Basic Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, Florida 32307, United States.
Edith B KuudaarDivision of Basic Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, Florida 32307, United States.
Alexus A MorganDivision of Basic Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, Florida 32307, United States.
Ismail L JonesDivision of Basic Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, Florida 32307, United States.
Eljaye W TellisDivision of Basic Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, Florida 32307, United States.
Seth Y AblordeppeyDivision of Basic Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, Florida 32307, United States.ORCID https://orcid.org/0000-0003-0174-1153

Funding

Research Project-3: Effectiveness of an eHealth intervention for uptake of cervical cancer screening in Hispanic womenU54MD007582 · NIMHD · FLORIDA AGRICULTURAL AND MECHANICAL UNIV · PI Syreeta L Tilghman · 2019 to 2026
$28.1M
Supplement to Discovery of a high affinity, selective and beta-arrestinbiased 5-HT7R Agonist GrantR16GM145581 · NIGMS · FLORIDA AGRICULTURAL AND MECHANICAL UNIV · PI ABLORDEPPEY, SETH Y · 2022 to 2025
$791k
NIGMS NIH HHS R16 GM145581NIMHD NIH HHS U54 MD007582
6 · The paper itself

Abstract

Central nervous system (CNS) disorders are multifactorial in nature. Dopamine (DA) and serotonin (5-HT) receptors are the prime targets for antipsychotic drug development. In particular, D

Identifiers

PMID42598466
PMCPMC13470933

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.