Evidence map›Paper›PMID 42598505›Full record

ArticleMolecular therapy. Nucleic acids2026

Quantum molecular resonance and secretome synergistically unlocks a protective ceRNA axis in the human retinal pigment epithelium.

Simona Alibrandi, Domenico Mordà, Concetta Scimone, Angela D'Ascola, Federica Aliquò, Giorgia Abate, Gianantonio Pozzato, Sergio Zaccaria Scalinci, Rosalia D'Angelo, Antonina Sidoti and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Simona AlibrandiDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, Division of Medical Biotechnologies and Preventive Medicine, University of Messina, 98125 Messina, Italy.
Domenico MordàDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, Division of Medical Biotechnologies and Preventive Medicine, University of Messina, 98125 Messina, Italy.
Concetta ScimoneDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, Division of Medical Biotechnologies and Preventive Medicine, University of Messina, 98125 Messina, Italy.
Angela D'AscolaDepartment of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
Federica AliquòDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, Division of Medical Biotechnologies and Preventive Medicine, University of Messina, 98125 Messina, Italy.
Giorgia AbateDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, Division of Medical Biotechnologies and Preventive Medicine, University of Messina, 98125 Messina, Italy.
Gianantonio PozzatoTelea Electronic Engineering Srl, 36066 Sandrigo, Italy.
Sergio Zaccaria ScalinciDepartment of Medical and Surgical Sciences, University of Bologna, 40121 Bologna, Italy.
Rosalia D'AngeloDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, Division of Medical Biotechnologies and Preventive Medicine, University of Messina, 98125 Messina, Italy.
Antonina SidotiDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, Division of Medical Biotechnologies and Preventive Medicine, University of Messina, 98125 Messina, Italy.
Luigi DonatoDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, Division of Medical Biotechnologies and Preventive Medicine, University of Messina, 98125 Messina, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The retinal pigment epithelium (RPE) contributes to retinal homeostasis in part through non-coding RNA (ncRNA) regulatory networks, and its degeneration underlies blinding diseases. How physical and paracrine regenerative stimuli affect the RPE non-coding transcriptome remains unknown. We performed RNA-seq on ARPE-19 cells in a full-factorial design of four treatments (CTRL, QMR, a patient blood-derived secretome, and QMR+SECRETOME) two oxidative-stress states (basal and tert-butyl hydroperoxide [tBHP]-induced), and three time points (8, 24, 72 h). lncRNAs and circRNAs were sub-classified and mapped via GO enrichment and in silico ceRNA prediction. PCA identified QMR as the dominant driver of transcriptomic variance, priming ARPE-19 cells to integrate paracrine signals. Analysis across six factorial contrasts identified 105 modulated non-coding transcripts, including a pan-responsive antisense core (

Indexed as

age-related macular degenerationcircRNAlncRNAMT: Non-coding RNAsquantum molecular resonanceretinal pigment epitheliumRNA-seqsecretome

Identifiers

PMID42598505
PMCPMC13471074

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.