Evidence map›Paper›PMID 42598644›Full record

ArticleBlood vessels, thrombosis & hemostasis2026

Acute therapy with hemopexin (CSL889) resolves LPS-induced lung vaso-occlusion in sickle mice.

Rikesh K Dubey, Ravi Vats, Thomas Gentinetta, Tomasz W Kaminski, Manikanta, Omika Katoch, Tirthadipa Pradhan-Sundd, Jesus Tejero, Brandon Greene, Gregory J Kato and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood vessels, thrombosis & hemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rikesh K DubeyThrombosis and Hemostasis Program, Versiti Blood Research Institute and Blood Center of Wisconsin, Milwaukee, WI.
Ravi VatsHeart, Lung, Blood, and Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.
Thomas GentinettaResearch and Development, CSL Behring AG, Schlieren, Switzerland.
Tomasz W KaminskiThrombosis and Hemostasis Program, Versiti Blood Research Institute and Blood Center of Wisconsin, Milwaukee, WI.
ManikantaThrombosis and Hemostasis Program, Versiti Blood Research Institute and Blood Center of Wisconsin, Milwaukee, WI.
Omika KatochThrombosis and Hemostasis Program, Versiti Blood Research Institute and Blood Center of Wisconsin, Milwaukee, WI.
Tirthadipa Pradhan-SunddThrombosis and Hemostasis Program, Versiti Blood Research Institute and Blood Center of Wisconsin, Milwaukee, WI.
Jesus TejeroHeart, Lung, Blood, and Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.
Brandon GreeneResearch & Development, CSL Innovation GmbH, Marburg, Germany.
Gregory J KatoResearch & Development, CSL Behring, King of Prussia, PA.
Paolo RossatoResearch & Development, CSL Innovation GmbH, Marburg, Germany.
Gerald HoebarthResearch & Development, CSL Innovation GmbH, Marburg, Germany.
Prithu SunddThrombosis and Hemostasis Program, Versiti Blood Research Institute and Blood Center of Wisconsin, Milwaukee, WI.

Funding

Pulmonary arteriole occlusion by platelet-neutrophil micro-emboli in Acute Chest SyndromeR01HL128297 · NHLBI · VERSITI WISCONSIN, INC. · PI SUNDD, PRITHU · 2015 to 2025
$5.4M
Mechanisms of platelet exosome-mediated acute chest syndrome in sickle cell diseaseR01HL141080 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEAL, MATTHEW D, NOVELLI, ENRICO M · 2019 to 2022
$3.1M
CD39-carrying extracellular vesicles regulate pulmonary thrombosis in Sickle Cell DiseaseR01HL166345 · NHLBI · VERSITI WISCONSIN, INC. · PI Prithu Sundd · 2023 to 2026
$3.1M
Molecular Mechanism of Sickle Cell Hepatic CrisisK01DK125617 · NIDDK · VERSITI WISCONSIN, INC. · PI PRADHAN-SUNDD, TIRTHADIPA · 2020 to 2024
$736k
NHLBI NIH HHS R01 HL128297NHLBI NIH HHS R01 HL141080NHLBI NIH HHS R01 HL166345NIDDK NIH HHS K01 DK125617
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID42598644
PMCPMC13471943

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.