Evidence map›Paper›PMID 42598656›Full record

ReviewBioactive materials2026

Biomaterial-based extracellular vesicle delivery systems for wound healing: From fabrication to applications.

Shengqiu Chen, Zhiliang Zhao, Lige Tian, Shengnan Cui, Xi Liu, Hao Meng, Yi Xie, Dawei Chen, Xingwu Ran, Changsheng Zhao and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shengqiu ChenInnovation Research Center for Diabetic Foot, West China Hospital, Sichuan University, Chengdu, 610041, China.
Zhiliang ZhaoTalent Office, West China Hospital, Sichuan University, Chengdu, 610041, China.
Lige TianMedical Innovation Research Department, Chinese PLA General Hospital and PLA Medical College, Beijing, 100048, China.
Shengnan CuiMedical Innovation Research Department, Chinese PLA General Hospital and PLA Medical College, Beijing, 100048, China.
Xi LiuMedical Innovation Research Department, Chinese PLA General Hospital and PLA Medical College, Beijing, 100048, China.
Hao MengMedical Innovation Research Department, Chinese PLA General Hospital and PLA Medical College, Beijing, 100048, China.
Yi XieCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.
Dawei ChenInnovation Research Center for Diabetic Foot, West China Hospital, Sichuan University, Chengdu, 610041, China.
Xingwu RanInnovation Research Center for Diabetic Foot, West China Hospital, Sichuan University, Chengdu, 610041, China.
Changsheng ZhaoCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.
Xiaobing FuMedical Innovation Research Department, Chinese PLA General Hospital and PLA Medical College, Beijing, 100048, China.
Cuiping ZhangMedical Innovation Research Department, Chinese PLA General Hospital and PLA Medical College, Beijing, 100048, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skin damage, especially chronic wounds, imposes a significant clinical burden due to the associated risks of disability and death. Extracellular vesicles (EVs) have received extensive attention due to their potential in wound healing. However, the rapid clearance and short retention time of EVs at wound sites hinder the optimal therapeutic effects. The latest advancements in biomaterial delivery systems have spurred the rapid development of engineered EV delivery systems. These biomaterials can not only prolong the localization and stability of EVs in wounds, but also provide structural and biochemical support for cell growth and tissue regeneration. This review provides a comprehensive overview of EVs and the fabrication strategies of EV delivery systems with diverse application forms. The release mechanisms, release profiles, mathematical kinetic models of EVs from biomaterials are also discussed. The application of these EV-loaded biomaterials in treating various types of wounds is also summarized and discussed. Finally, current challenges and future directions in EV-based wound treatment are proposed. Unlike previous reviews that focused separately on the biology of EVs or biomaterials as wound dressings, this review presents a comprehensive summary of the fabrication strategies and applications of advanced biomaterial-based EV delivery platforms for wound healing.

Indexed as

BiomaterialsDelivery systemExtracellular vesicleRelease mechanismWound healing

Identifiers

PMID42598656
PMCPMC13472037

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.