ArticleJournal of pharmacy & bioallied sciences
Cytotoxicity Test of Ethyl Acetate Fraction of
Article in Journal of pharmacy & bioallied sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Breast cancer and colon cancer are critical problems today that require effective and safe treatment. Long-term use of synthetic drugs can cause high side effects; therefore, natural-based chemopreventive agents are an option. Melinjo seeds are known for their resveratrol compounds which have been proven as chemopreventive agents. Meanwhile, catechins are polyphenols that are effective as antioxidants and anticancer agents. This study aims to determine the cytotoxic effect of the ethyl acetate fraction of melinjo seeds on breast and colon cancer cells based on the activity of catechin compounds. Methods: This study is experimental. Extraction was carried out by soxhletation method, followed by fractionation using ethanol and ethyl acetate (1:1, v/v). Identification of catechin in the ethyl acetate fraction of melinjo seeds was performed using high-performance liquid chromatography (HPLC). Cytotoxic testing was carried out Results: The results of the study showed that the IC Conclusion: This study proves that the ethyl acetate fraction of melinjo seeds has a moderate cytotoxic effect on MCF-7 breast and CACO-2 colon cancer cells. It is suggested that catechins may play a role in this ytotoxic effect. Further research is needed to determine the cellular action of catechins that supports their cytotoxic effect.
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