Evidence map›Paper›PMID 42599328›Full record

ReviewMolecular biology reports2026

Non-Drug therapeutic strategies to combat antimicrobial resistance in livestock: a review.

Dejen Asaye Mengistu, Yesuneh Tefera Mekasha, Fentahun Wondmnew Molla

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dejen Asaye MengistuDepartment of Veterinary Clinical Medicine, School of Veterinary Medicine, Bahir Dar University, P.O.Box 79, Bahir Dar, Ethiopia. dejuvet2002@gmail.com.ORCID http://orcid.org/0009-0005-6350-5000
Yesuneh Tefera MekashaBioequivalence Center, Clinical Trials Directorate, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.
Fentahun Wondmnew MollaDepartment of Immunology Research, Animal Health Institute, P.O.Box 04, Sebeta, Addis Ababa, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntimicrobial resistance (AMR) represents an escalating global public health crisis, projected to cause 10 million deaths annually by 2050. Pathogens such as bacteria, viruses, fungi, and parasites evade treatments in animals and humans due to overuse and misuse of antimicrobials, particularly antibiotics, in medical and veterinary practices. This drives a worldwide surge in resistant infections, disproportionately burdening livestock health and productivity.

objectivesThis review examines the global rise of AMR and its impacts on livestock and public health, underscoring the need for non-drug therapeutic alternatives.

conclusionPromising alternatives include genetic engineering and CRISPR-Cas systems, phage therapy, probiotics, antimicrobial peptides, fecal microbiota transplantation, phytotherapy and essential oils, immunomodulators, nanotechnology, biofilm disruptors, acidifiers, vaccination strategies, and precision livestock farming. These approaches target resistance mechanisms without relying on conventional drugs. Despite challenges like knowledge gaps, regulatory barriers, financial limitations, and policy gaps, stakeholders must prioritize accelerated research, regulatory reforms, investments, and international collaboration. Rapid integration of these technologies into human and veterinary medicine is vital to mitigate AMR's health, economic, and social impacts.

Indexed as

Drug Resistance, MicrobialLivestockAnimalsAnti-Bacterial AgentsAnti-Infective AgentsCRISPR-Cas SystemsFecal Microbiota TransplantationGenetic EngineeringHumansPhage TherapyProbioticsAnti-Bacterial AgentsAnti-Infective AgentsAlternative therapeutic technologiesAntimicrobial resistanceCRISPR/Cas9LivestockNanotechnologyPhage therapyProbiotics

Identifiers

PMID42599328

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.