Evidence map›Paper›PMID 42599532›Full record

ReviewMolecular biology reports2026

Unravelling the phytochemical complexity of neuroprotective plants: a metabolomics approach to Alzheimer's disease.

Shubatra Nahenthara Raj, Maya Erna Natnan, Wong Pei Lou, Ahmed Mediani, Tewin Tencomnao, Syarul Nataqain Baharum

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shubatra Nahenthara Raj *Metabolomics Research Laboratory, Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia, Bangi, 43600 UKM, Selangor, Malaysia.
Maya Erna Natnan *Metabolomics Research Laboratory, Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia, Bangi, 43600 UKM, Selangor, Malaysia.
Wong Pei LouMetabolomics Research Laboratory, Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia, Bangi, 43600 UKM, Selangor, Malaysia.
Ahmed MedianiMetabolomics Research Laboratory, Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia, Bangi, 43600 UKM, Selangor, Malaysia.
Tewin TencomnaoDepartment of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.
Syarul Nataqain BaharumMetabolomics Research Laboratory, Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia, Bangi, 43600 UKM, Selangor, Malaysia. nataqain@ukm.edu.my.

Funding

Universiti Kebangsaan Malaysia GGP-2020-043
6 · The paper itself

Abstract

Metabolomics is a comprehensive study of organisms at the metabolite level. The emergence of metabolomics as one of the 'omics' in systems biology perspectives has gained significance in relation to disease research. The use of metabolomics pipeline to unravel the potential of bioactive compounds in medicinal plants for benefiting mankind has become a powerful strategy for drug discovery. While traditional metabolite profiling has mainly classified medicinal plants according to broad biological activities, such as anti-inflammatory, anticancer, anti-diabetic and atherosclerosis effects, the non-targeted and targeted metabolomics offer a comprehensive approach for characterizing novel or previously unknown secondary metabolites providing a far more detailed approach. These advanced methodologies allow researchers to expand current research by providing deeper insight into how these compounds work and their underlying mechanisms at the molecular level. To investigate these metabolic shifts particularly in neurodegenerative diseases model, studies frequently use advanced analytical platform, such as nuclear magnetic resonance (NMR), gas chromatography-mass spectrometry (GC-MS), and liquid chromatography-mass spectrometry (LC-MS) to analyze metabolites in biofluids like blood, urine, and cerebrospinal fluid (CSF). This review will highlight recent metabolomics discoveries on unravelling the complex phytochemical composition of selected medicinal plants in producing neuroprotective bioactive compounds and therapeutic potential to combat neurodegenerative related disease especially Alzheimer's disease (AD).

Indexed as

Alzheimer DiseaseMetabolomicsNeuroprotective AgentsPhytochemicalsPlants, MedicinalAnimalsDrug DiscoveryHumansMetabolomeNeuroprotective AgentsPhytochemicalsAlzheimer’s disease (AD)Bioactive compoundDrug discoveryMetabolomicsNatural product

Identifiers

PMID42599532

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.