ArticleBiological trace element research2026
Roles of External Factors and Polygenic Susceptibility in Thyroid Nodules and Goiter Among Children Aged 8-10 Years in Iodine-adequate Areas of Northern China.
Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Thyroid nodules and goiter remain common conditions affecting healthy child development, attributable to diagnostic advances and environmental-genetic interactions. However, pediatric etiology research remains limited. A total of 997 children aged 8 to 10 years were recruited from iodine-adequate areas across 13 districts in Tianjin, China. Venous blood was collected for genotyping three single nucleotide polymorphisms (thyroid stimulating hormone receptor (TSHR) rs2268458, thyroid transcription factor 1 (TTF1) rs2076735 and phosphodiesterase 8B (PDE8B) rs4704397) using Sequenom MassARRAY. Data on up to 30 potential external factors were also collected. The detection rates of thyroid nodules and goiter were 23.57% and 8.83%, respectively. Gender, higher body surface area (BSA) (Q4: >1.30 m
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