Evidence map›Paper›PMID 42599664›Full record

ArticleChemistry & biodiversity2026

Design, Synthesis, Antifeedant Activity, and Mechanistic Research of Aconitine Derivatives.

Lin Chen, Xin-Pei Wu, Cheng-En Fu, Hong-Ying Chen, Shuai Huang, Xian-Li Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lin ChenSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, People's Republic of China.ORCID https://orcid.org/0000-0001-5423-4708
Xin-Pei WuSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, People's Republic of China.
Cheng-En FuSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, People's Republic of China.
Hong-Ying ChenSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, People's Republic of China.
Shuai HuangSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, People's Republic of China.
Xian-Li ZhouSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, People's Republic of China.

Funding

National Natural Science Foundation of China 21807089Special Research Funds for the University‑Local Government Cooperation Agreement of Yibin City YBSCXY2023020005
6 · The paper itself

Abstract

For decades, natural product-derived insect repellents have been a major focus of research. Aconitine, a diterpene alkaloid isolated from Aconitum plants, exhibits not only significant antifeedant activity but also potent toxicological effects against certain insects. In this study, 48 novel aconitine derivatives were synthesized via esterification of the C3-hydroxyl group. Among them, compound A4 demonstrated optimum antifeedant activity with an AFC

Indexed as

AconitineDrug DesignFeeding BehaviorInsect RepellentsAnimalsApoptosisCell SurvivalDose-Response Relationship, DrugMolecular StructureSpodopteraStructure-Activity RelationshipAconitineInsect Repellentsaconitine derivativesantifeedant activityapoptosis mechanismSF9 cell toxicity

Identifiers

PMID42599664
PMCPMC13475582

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.