Design, synthesis and antiviral activity of ciclopirox (CPX) analogs against orthopoxvirus.

D M Nirosh Udayanga, Ziyue Wang, Anil Pant, Ajit D Jagtap, Zhilong Yang, Zhengqiang Wang

Abstract read

In one paragraph

Article in Bioorganic & medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

D M Nirosh UdayangaCenter for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.

Ziyue WangDepartment of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.

Anil PantDepartment of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.

Ajit D JagtapCenter for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.

Zhilong YangDepartment of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA. Electronic address: zhilongyang@tamu.edu.

Zhengqiang WangCenter for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: wangx472@umn.edu.

Funding

Development of novel antivirals against mpox (monkeypox) virusR01AI183580 · NIAID · UNIVERSITY OF MINNESOTA · PI Zhengqiang Wang, Zhilong Yang · 2024 to 2026

$2.3M

NIAID NIH HHS R01 AI183580

6 · The paper itself

Abstract

In search for structurally novel antiviral leads against orthopoxvirus, we have previously identified and characterized ciclopirox (CPX) as a strong antiviral hit inhibiting vaccinia virus (VACV) replication. We report herein the antiviral activity-guided structure-activity relationship (SAR) of CPX, probing three structural zones (R

Indexed as

Antiviral AgentsDrug DesignOrthopoxvirusPyridonesAnimalsCiclopiroxDose-Response Relationship, DrugHumansMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipVaccinia virusVirus ReplicationAntiviral AgentsCiclopiroxPyridonesAntiviralCiclopiroxOrthopoxvirusSARVaccinia virus

Identifiers

PMID42600444

DOI10.1016/j.bmc.2026.118775

PMCPMC13485336

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.