Evidence map›Paper›PMID 42600613›Full record

ArticleCell2026

Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcriptional program in mouse and human.

Simone Brioschi, Julia A Belk, Steffen E Storck, Yue Wu, Zhuoying Wang, Ziang Feng, Lynn van Olst, Josie L Emery, Raki Sudan, Junjie Wu and 32 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors.

Simone BrioschiDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA; Center for Neuroimmunology and Glial Biology, Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA. Electronic address: simone.brioschi@uth.tmc.edu.
Julia A BelkDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Steffen E StorckDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA; Brain Immunology and Glia (BIG) Center, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA.
Yue WuDepartment of Biomedical Engineering, James McKelvey School of Engineering Washington University in St. Louis, St. Louis, MO 63130, USA.
Zhuoying WangDepartment of Biomedical Engineering, James McKelvey School of Engineering Washington University in St. Louis, St. Louis, MO 63130, USA.
Ziang FengDepartment of Biomedical Engineering, James McKelvey School of Engineering Washington University in St. Louis, St. Louis, MO 63130, USA.
Lynn van OlstAbrams Research Center on Neurogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Biomedical Sciences, University of Groningen, University Medical Center Groningen, Groningen 9700AD, the Netherlands.
Josie L EmeryDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Raki SudanDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA.
Junjie WuDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA.
Siling DuDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA.
Marco GenuaSan Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.
Federica La TerzaSan Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.
Alex J EdwardsAbrams Research Center on Neurogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Khai M NguyenDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA.
Jessie SanfordDepartment of Psychiatry, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA; NeuroGenomics and Informatics Center, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA.
Daniel D LeeDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA.
Mattia BugattiDepartment of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Italy.
Arnold J FedericoDepartment of Genetics, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA.
Yun ChenDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA.
Zuoxu WangDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA.
Silvia PenatiDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA.
Patrick Fernandes RodriguesDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA; Institute of Experimental Immunology, University of Zurich, Zurich 8057, Switzerland.
Alina Ulezko AntonovaDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA.
Hui Qi LooDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA.
Igor SmirnovDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA; Brain Immunology and Glia (BIG) Center, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA.
Susan GilfillanDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA.
Carmen M HalabiDepartment of Pediatrics, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA.
Jennifer PonceMcDonnell Genome Institute, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA.
Jun YanDivision of Immunotherapy, The Hiram C. Polk, Jr., MD Department of Surgery, Immuno-Oncology Program, Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Howard Y ChangDepartments of Dermatology and Genetics, Stanford University, Stanford, CA 94305, USA.
Gwendalyn J RandolphDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA.
William VermiDepartment of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Italy.
Marina CellaDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA.
Michael MeersDepartment of Genetics, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA.
Renato OstuniSan Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan 20132, Italy; Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.
David GateAbrams Research Center on Neurogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Aivi T NguyenDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Carlos CruchagaDepartment of Psychiatry, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA; NeuroGenomics and Informatics Center, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA.
Song HuDepartment of Biomedical Engineering, James McKelvey School of Engineering Washington University in St. Louis, St. Louis, MO 63130, USA.
Jonathan KipnisDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA; Brain Immunology and Glia (BIG) Center, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA; Brain Immunology and Glia (BIG) Center, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: mcolonna@mgh.harvard.edu.

Funding

The protein tyrosine kinase SYK drives innate immune responses against Alzheimer's DiseaseP01AG078106 · NIA · WASHINGTON UNIVERSITY · PI MARCO COLONNA · 2022 to 2026
$18.4M
PRINCIPLES IN CARDIVASCULAR RESEARCH TRAINING PROGRAMT32HL007081 · NHLBI · WASHINGTON UNIVERSITY · PI Abhinav Diwan, Karen Ellen Joynt Maddox · 1985 to 2026
$10.6M
TREM2 IN MICROGLIA BIOLOGY AND ALZHEIMER'S DISEASERF1AG051485 · NIA · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2015 to 2021
$3.5M
Ontogenetic niche of B cells at the CNS borders in homeostasis, aging and autoimmunityR01AI158579 · NIAID · WASHINGTON UNIVERSITY · PI MARCO COLONNA, ALESSANDRA B PERNIS · 2022 to 2026
$3.0M
Spontaneous and Induced B cell and T cell responses in Alzheimer's DiseaseR01AG081631 · NIA · WASHINGTON UNIVERSITY · PI MARCO COLONNA · 2024 to 2026
$2.3M
Understanding Pancreatic Cancer Immune Microenvironment and Treatment Response through Integrating in vivo Imaging with ImmunophenotypingR01CA278941 · NCI · UNIVERSITY OF LOUISVILLE · PI Haixun Guo, JUN YAN · 2024 to 2026
$1.9M
TREM2 IN MICROGLIA BIOLOGY AND ALZHEIMER'S DISEASER01AG051485 · NIA · WASHINGTON UNIVERSITY · PI MARCO COLONNA · 2024 to 2026
$1.7M
Elucidating the mechanisms by which microgliopathy causes early-onset dementiaR21AG085133 · NIA · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2024 to 2024
$428k
NCI NIH HHS R01 CA278941NHLBI NIH HHS T32 HL007081NIAID NIH HHS R01 AI158579NIA NIH HHS P01 AG078106NIA NIH HHS R01 AG051485NIA NIH HHS R01 AG081631NIA NIH HHS R21 AG085133NIA NIH HHS RF1 AG051485
6 · The paper itself

Abstract

Brain perivascular macrophages maintain brain physiology, yet their transcriptional regulators and functions in health and disease remain unclear. Using single-cell multi-omics and functional experiments, we identify cellular musculoaponeurotic fibrosarcoma oncogene (cMAF) as a key transcription factor for brain perivascular macrophages, and conditional deletion of cMAF disrupts their phenotype in vivo. Functionally, cMAF drives insulin-like growth factor-1 (IGF1) expression in perivascular macrophages, enabling communication with endothelial cells. Consistently, cMAF deletion in perivascular macrophages causes transcriptional alterations in cerebral arteries, affecting vascular functions. Notably, cMAF emerges as the main transcription factor for human perivascular macrophages, suggesting conservation of this transcriptional module. During Alzheimer's disease (AD), human perivascular macrophages upregulate cMAF and IGF1 to enhance communication with vascular cells, and this response is abrogated in APOE4 carriers. Lastly, we explore an uncharacterized polymorphism in cMAF, providing evidence that the cMAF program is protective against AD. Targeting cMAF in perivascular macrophages may offer new therapeutic strategies for neurodegenerative and cerebrovascular diseases.

Indexed as

Alzheimer's diseaseAPOE4arteriescerebral blood flowcerebrospinal fluidcMAFIGF1immune-vascular axismicrogliaperivascular macrophages

Identifiers

PMID42600613
PMCPMC13546755

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.