Evidence map›Paper›PMID 42601377›Full record

ArticleScientific reports2026

Personality variability during development predicts alcohol use before and during the COVID-19 pandemic.

Rabia Zohair, Karina Janson, Sebastian Siehl, Arun L W Bokde, Sylvane Desrivières, Hugh Garavan, Penny Gowland, Antoine Grigis, Andreas Heinz, Jean-Luc Martinot and 19 more

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

29 authors.

Rabia Zohair *Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Kiel, Germany.
Karina Janson *Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Kiel, Germany.
Sebastian SiehlInstitute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Kiel, Germany.
Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Sylvane DesrivièresCentre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, London, UK.
Hugh GaravanDepartments of Psychiatry and Psychology, University of Vermont, Burlington, VT, 05405, USA.
Penny GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK.
Antoine GrigisUniversité Paris-Saclay, CEA, CNRS, BAOBAB, Gif-sur-Yvette, 91191, France.
Andreas HeinzDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
Jean-Luc MartinotDepartment of Child and Adolescent Psychiatry, INSERM U A10 Trajectoires développementales & psychiatrie, AP-HP. Sorbonne Université, Pitié-Salpêtrière Hospital, Institut National de la Santé et de la Recherce Médicale, University Paris-Saclay, Ecole Normale Supérieure Paris- Saclay, CNRS; Centre Borelli, Gif-sur-Yvette, Paris, France.
Marie-Laure Paillère MartinotDepartment of Child and Adolescent Psychiatry, INSERM U A10 Trajectoires développementales & psychiatrie, AP-HP. Sorbonne Université, Pitié-Salpêtrière Hospital, Institut National de la Santé et de la Recherce Médicale, University Paris-Saclay, Ecole Normale Supérieure Paris- Saclay, CNRS; Centre Borelli, Gif-sur-Yvette, Paris, France.
Eric ArtigesDepartment of Child and Adolescent Psychiatry, INSERM U A10 Trajectoires développementales & psychiatrie, AP-HP. Sorbonne Université, Pitié-Salpêtrière Hospital, Institut National de la Santé et de la Recherce Médicale, University Paris-Saclay, Ecole Normale Supérieure Paris- Saclay, CNRS; Centre Borelli, Gif-sur-Yvette, Paris, France.
Dimitri Papadopoulos OrfanosUniversité Paris-Saclay, CEA, CNRS, BAOBAB, Gif-sur-Yvette, 91191, France.
Tomáš PausDepartment of Psychiatry, Faculty of Medicine and Centre Hospitalier Universitaire Sainte- Justine, University of Montreal, Montreal, QC, Canada.
Luise PoustkaDepartment of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Square J5, 68159, Mannheim, Germany.
Michael N SmolkaDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Nathalie E HolzDepartment of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Square J5, 68159, Mannheim, Germany.
Nilakshi VaidyaDepartment of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Square J5, 68159, Mannheim, Germany.
Henrik WalterDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
Robert WhelanSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
Gunter SchumannCentre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin, Berlin, Germany.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Square J5, 68159, Mannheim, Germany.
Herta FlorInstitute of Cognitive and Clinical Neuroscience, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Square J5, Mannheim, Germany.
Olaf ReisDepartment of Child and Adolescent Psychiatry, University Medical Centre Rostock, German Center for Child and Adolescent Health (DZKJ), Partner site Greifswald/Rostock, Rostock Germany, Gehlsheimer Str. 20, 18147, Rostock, Germany.
Emanuel SchwarzGerman Center for Mental Health (DZPG), Partner Site Mannheim-Heidelberg-Ulm, Mannheim, Germany.
IMAGEN Consortium
CoviDrug Consortium
Christoph BorzikowskyInstitute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Kiel, Germany.
Frauke NeesInstitute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Kiel, Germany. frauke.nees@med.uni-muenchen.de.

Funding

Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
A decentralized macro and micro gene-by-environment interaction analysis of substance use behavior and its brain biomarkers R01DA049238 · NIDA · GEORGIA STATE UNIVERSITY · PI CALHOUN, VINCE D, LIU, JINGYU · 2019 to 2023
$2.9M
ENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683k
NIA NIH HHS R56 AG058854NIBIB NIH HHS U54 EB020403NIDA NIH HHS R01 DA049238
6 · The paper itself

Abstract

Changes in personality during adolescence may shape future alcohol use, especially in times of societal crisis. The COVID-19 pandemic disrupted social norms and stress regulation, making it a natural experiment to examine how early-life personality trajectories predict later substance use. Using longitudinal data from the European IMAGEN cohort (N = 968), we investigated whether intra-individual personality changes during adolescence predicted alcohol use at three timepoints: pre-pandemic, immediately after COVID-19 onset (T1), and several months into the pandemic (T2). Generalized Additive Mixed Models (GAMMs) were used to model non-linear relationships between adolescent personality change (e.g., in anxiety sensitivity and openness) and alcohol use frequency across time. Participants were drawn from the IMAGEN cohort (N = 968; 54.4% female), assessed longitudinally from early adolescence (BL: M = 13.93, SD = 0.41) through middle (FU1: M = 16.04, SD = 0.60) and late adolescence (FU2: M = 18.41, SD = 0.65) to early adulthood (FU3: M = 22.00, SD = 0.66), with additional follow-ups during the COVID-19 pandemic (COVID-T1: M = 25.00, SD = 0.81; COVID-T2: M = 25.56, SD = 0.75). Assessments were conducted at approximately 2-year intervals during adolescence and at shorter intervals (several months) during the COVID-19 period. Analyses controlled for sex and country-level lockdown stringency. Intra-individual fluctuations in anxiety sensitivity significantly predicted increased alcohol use several months into the pandemic (T2; EDF = 1.86, p < 0.05), but not immediately after lockdown (T1). Pre-pandemic alcohol use was instead associated with changes in openness (EDF = 1.00, p < 0.05). Exploratory analyses suggested gender differences in anxiety-related drinking risk. Our findings suggest that personality dynamics in adolescence shape alcohol use responses during societal crises. Different traits appear to matter depending on the temporal and emotional context of the stressor. These findings have implications for personalized prevention efforts targeting stress-related substance use in youth.

Indexed as

Alcohol DrinkingCOVID-19PersonalityAdolescentAnxietyFemaleHumansLongitudinal StudiesMalePandemicsSARS-CoV-2AdolescentsAlcohol abuseCOVID-19 pandemicNegative life eventsPersonality development

Identifiers

PMID42601377
PMCPMC13476260

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.