Evidence map›Paper›PMID 42601407›Full record

ArticleNature aging2026

Physical activity delays ovarian aging in part through adiponectin-related signaling pathways.

Biao Li, Nana Zheng, Tong Luo, Yueqi Chen, Xionge Mei, Qiyuan Huang, Wei Wang, Longyan Li, Lincheng Han, Wanying Wang and 11 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Nature aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Biao Li *Key Laboratory of Sleep and Biological Rhythms of Guangdong Province, Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.ORCID http://orcid.org/0009-0000-7885-0353
Nana Zheng *Key Laboratory of Sleep and Biological Rhythms of Guangdong Province, Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China. zhengnn@gzhmu.edu.cn.ORCID http://orcid.org/0000-0001-9683-7945
Tong Luo *Key Laboratory of Sleep and Biological Rhythms of Guangdong Province, Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.ORCID http://orcid.org/0009-0000-2876-6970
Yueqi ChenDepartment of Dental Public Health, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID http://orcid.org/0009-0008-2328-4137
Xionge MeiKey Laboratory of Sleep and Biological Rhythms of Guangdong Province, Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Qiyuan HuangKey Laboratory of Sleep and Biological Rhythms of Guangdong Province, Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Wei WangKey Laboratory of Sleep and Biological Rhythms of Guangdong Province, Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.ORCID http://orcid.org/0000-0002-4206-9298
Longyan LiKey Laboratory of Sleep and Biological Rhythms of Guangdong Province, Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Lincheng HanKey Laboratory of Sleep and Biological Rhythms of Guangdong Province, Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Wanying WangKey Laboratory of Sleep and Biological Rhythms of Guangdong Province, Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Bingqin LinKey Laboratory of Sleep and Biological Rhythms of Guangdong Province, Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Yimei FanKey Laboratory of Sleep and Biological Rhythms of Guangdong Province, Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Yaping LiuKey Laboratory of Sleep and Biological Rhythms of Guangdong Province, Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Zili LiuKey Laboratory of Sleep and Biological Rhythms of Guangdong Province, Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Sizhi AiKey Laboratory of Sleep and Biological Rhythms of Guangdong Province, Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Yannis Yan LiangKey Laboratory of Sleep and Biological Rhythms of Guangdong Province, Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.ORCID http://orcid.org/0000-0002-6417-4881
Han WangSchool of Biology & Basic Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, China.
Xiao TanDepartment of Psychiatry, Sir Run Shaw Hospital and Department of Big Data in Health Science, School of Public Health, Zhejiang University School of Medicine, Hangzhou, China.ORCID http://orcid.org/0000-0003-3992-5812
Meijia ZhangThe Innovation Centre of Ministry of Education for Development and Diseases, School of Medicine, South China University of Technology, Guangzhou, China.
Hongliang FengKey Laboratory of Sleep and Biological Rhythms of Guangdong Province, Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China. hlfeng@gzhmu.edu.cn.ORCID http://orcid.org/0000-0003-3291-7780
Jihui ZhangKey Laboratory of Sleep and Biological Rhythms of Guangdong Province, Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China. zhangjihui@gzhmu.edu.cn.ORCID http://orcid.org/0000-0002-4976-3039

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian aging leads to infertility, endocrine dysregulation and increased chronic disease risk, yet there are currently no approved therapies to delay ovarian aging. Physical activity (PA) is a crucial lifestyle factor for human health and antiaging, but its effects and mechanisms on ovarian aging remain unclear. Here we show, through a cross-sectional analysis of 152,435 participants in the UK Biobank, that lower PA levels were observed among postmenopausal persons when compared to premenopausal persons, and this finding was supported by another cross-sectional study of 12,418 participants in the National Health and Nutrition Examination Survey. Animal studies in mice show that higher levels of PA can delay ovarian aging. In addition, PA significantly increased adiponectin levels in the ovary, and the protective effects of PA on ovarian aging were attenuated in adiponectin-deficient mice. The adiponectin receptor agonist AdipoRon delayed ovarian aging and extended reproductive lifespan in mice. Our findings elucidate the role and mechanisms of PA in delaying ovarian aging, highlighting potential therapeutic targets for extending the reproductive lifespan.

Indexed as

AdiponectinAgingOvarySignal TransductionAdultAnimalsCross-Sectional StudiesFemaleHumansMiceMice, KnockoutMiddle AgedPiperidinesPostmenopauseReceptors, AdiponectinAdiponectinAdipoRonPiperidinesReceptors, Adiponectin

Identifiers

PMID42601407

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.