Evidence map›Paper›PMID 42601545›Full record

ArticleGeroScience2026

Dysregulated lncRNAs are associated with the progressive arterial phenotype in Hutchinson-Gilford Progeria Syndrome.

Lara G Merino, Santhilal Subhash, Daniel Whisenant, Shalini Gupta, Gwladys Revêchon, Maria Eriksson

Abstract read
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In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lara G MerinoDepartment of Medicine Huddinge, Karolinska Institutet, Huddinge, Sweden. lara.garcia.merino@ki.se.
Santhilal SubhashDepartment of Medicine Huddinge, Karolinska Institutet, Huddinge, Sweden.
Daniel WhisenantDepartment of Medicine Huddinge, Karolinska Institutet, Huddinge, Sweden.
Shalini GuptaDepartment of Biosciences and Bioengineering, Indian Institute of Technology Jammu, Jammu, India.
Gwladys RevêchonDepartment of Medicine Huddinge, Karolinska Institutet, Huddinge, Sweden.
Maria ErikssonDepartment of Medicine Huddinge, Karolinska Institutet, Huddinge, Sweden. maria.eriksson.2@ki.se.ORCID http://orcid.org/0000-0003-3233-2862

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare premature aging disorder caused by de novo LMNA mutations. Patients develop severe systemic symptoms limiting life quality and ultimately causing death from cardiovascular events. Despite extensive research, treatment options remain limited. Here, we investigated the role of long non-coding RNAs (lncRNAs) in the development of vascular pathology in HGPS. We analyzed an available single-cell RNA sequencing dataset from aortic arch cells of wild-type and Lmna

Indexed as

AgingLncRNAsProgeriaVSMCs

Identifiers

PMID42601545

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.