Evidence map›Paper›PMID 42602495›Full record

ArticleBioactive materials2027

Rosmarinic acid-cerium nanocatalysts enable oxygenation-enhanced ROS neutralization and PET imaging-guided therapy for acute kidney injury.

Yajie Zhao, Lu Hao, Jessica C Hsu, Ying Peng, Zhisheng Luo, Shijun Xiang, Yilan Wang, Jonathan W Engle, Xingchen Zhou, Shuo Hu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yajie ZhaoDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, 410008, China.
Lu HaoDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, 410008, China.
Jessica C HsuDepartments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Ying PengEye Center of Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Zhisheng LuoDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, 410008, China.
Shijun XiangDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, 410008, China.
Yilan WangDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, 410008, China.
Jonathan W EngleDepartments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, USA.
Xingchen ZhouDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410008, China.
Shuo HuDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, 410008, China.
Peng LiuDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, 410008, China.
Weibo CaiDepartments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, 53705, USA.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
NCI NIH HHS P30 CA014520
6 · The paper itself

Abstract

Acute kidney injury (AKI) is driven by a vicious interplay among excessive reactive oxygen species (ROS) accumulation and persistent renal hypoxia, which collectively disrupt redox homeostasis and exacerbate tubular injury. However, current therapeutic strategies primarily provide supportive care and fail to simultaneously modulate these interconnected pathological stressors. Herein, we report a cerium-doped rosmarinic acid nanosystem (RA/Ce NPs) formed via self-polymerization that catalytically eliminates ROS while simultaneously generating oxygen to reprogram the pathological renal microenvironment. The ultrasmall RA/Ce NPs enable efficient chelator-free

Indexed as

Acute kidney injuryCerium-doped rosmarinic acid nanosystemOxygenationPET imagingReactive oxygen species

Identifiers

PMID42602495
PMCPMC13474023

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.