Evidence map›Paper›PMID 42604239›Full record

ArticleCureus2026

Helicobacter pylori Resistance: Morphomolecular Analysis of Formalin-Fixed Paraffin-Embedded (FFPE) Biopsy Specimens From 374 Patients.

Torsten Hansen, Mathias Diederichs, Norbert Arens, Helena Philipps, Martin Balsliemke, Hauke Heinzow, Erwin Rambusch, Stefan Burg, Katharina Kriegsmann, Mark Kriegsmann and 1 more

Abstract read
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Torsten HansenPathology, Medical Care Center for Histology, Cytology, and Molecular Diagnostics Trier GmbH, Trier, DEU.
Mathias DiederichsPathology, Medical Care Center for Histology, Cytology, and Molecular Diagnostics Trier GmbH, Trier, DEU.
Norbert ArensPathology, Medical Care Center for Histology, Cytology, and Molecular Diagnostics Trier GmbH, Trier, DEU.
Helena PhilippsPathology, Medical Care Center for Histology, Cytology, and Molecular Diagnostics Trier GmbH, Trier, DEU.
Martin BalsliemkeInternal Medicine II, Verbundkrankenhaus Bernkastel/Wittlich, Wittlich, DEU.
Hauke HeinzowInternal Medicine II, Krankenhaus der Barmherzigen Brüder Trier, Trier, DEU.
Erwin RambuschInternal Medicine I, Klinikum Mutterhaus der Borromäerinnen gGmbH, Trier, DEU.
Stefan BurgInternal Medicine, Kreiskrankenhaus Saarburg, Saarburg, DEU.
Katharina KriegsmannClinical Chemistry, Rhein-Main Laboratory Medicine Practice MVZ GbR, Frankfurt, DEU.
Mark KriegsmannPathology, Center for Histology, Cytology and Molecular Pathology, Wiesbaden, DEU.
Joerg B KriegsmannPathology, Medical Care Center for Histology, Cytology, and Molecular Diagnostics Trier GmbH, Trier, DEU.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntibiotic resistance is the leading cause of

objectiveThis study aimed to investigate associations between histopathological findings and molecularly detected antibiotic resistance in

methodsWe analyzed FFPE biopsy specimens of 374 patients with

resultsWe found 67.1% resistance-associated mutations, most of them with R-CLA (n = 163; 64.9%), followed by R-CLA×FLU (n = 52; 20.7%) and R-FLU (n = 36; 14.3%). Overall, gastritis activity was mild in 213 patients (57%), moderate in 118 (31.6%), and severe in 20 (5.3%); chronic gastritis was absent in 23 patients (6.1%), mild in 87 (23.3%), moderate in 224 (59.9%), and severe in 63 (16.8%).

conclusionsMorphomolecular analysis of FFPE gastric biopsies represents a practical approach for routine

Indexed as

atrophyclarithromycinffpefluoroquinoloneshistologyh. pylorih. pylori densitymolecular pathologyresistance

Identifiers

PMID42604239
PMCPMC13477268

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.