Evidence map›Paper›PMID 42604297›Full record

ArticleJTCVS open2026

Sodium bicarbonate attenuates myocardial ischemia-reperfusion injury via activation of the splenic cholinergic anti-inflammatory pathway.

Emily P Rabinovich, Matthew Weber, Radhika Rastogi, Katherine M Marsh, Aimee Zhang, Irving L Kron, Zequan Yang

Abstract read
In one paragraph

Article in JTCVS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emily P RabinovichDepartment of Surgery, University of Virginia Health System, Charlottesville, Va.
Matthew WeberDepartment of Surgery, University of Virginia Health System, Charlottesville, Va.
Radhika RastogiDepartment of Surgery, University of Virginia Health System, Charlottesville, Va.
Katherine M MarshDepartment of Surgery, University of Virginia Health System, Charlottesville, Va.
Aimee ZhangDepartment of Surgery, University of Virginia Health System, Charlottesville, Va.
Irving L KronDepartment of Surgery, University of Virginia Health System, Charlottesville, Va.
Zequan YangDepartment of Surgery, University of Virginia Health System, Charlottesville, Va.

Funding

Cardiovascular Surgery Training ProgramT32HL007849 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI KRON, IRVING L., LAUBACH, VICTOR E · 1998 to 2025
$7.0M
A cardio-splenic-NET axis mediates acute MI and post-MI heart failureR01HL180693 · NHLBI · UNIVERSITY OF VIRGINIA · PI Yongqing Li, ZEQUAN YANG · 2026 to 2026
$1.6M
NCI NIH HHS L30 CA305688NHLBI NIH HHS R01 HL180693NHLBI NIH HHS T32 HL007849
6 · The paper itself

Abstract

Objective: The spleen plays a central role in mediating inflammatory responses during myocardial ischemia-reperfusion injury (IRI) via a neuroimmune axis involving vagal signaling and cholinergic modulation. Sodium bicarbonate (NaHCO Methods: C57BL/6 mice underwent 40 minutes of left coronary artery occlusion, followed by 60 minutes of reperfusion. Ten minutes before reperfusion, mice received either intravenous phosphate-buffered saline, NaHCO Results: Assessed risk region was comparable across groups. Intravenous NaHCO Conclusions: Acute NaHCO

Indexed as

cholinergic anti-inflammatory pathwaymyocardial ischemia-reperfusion injuryneuroimmune regulationsodium bicarbonatesplenic immunomodulation

Identifiers

PMID42604297
PMCPMC13477002

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.