ReviewHelicobacter
School-Based Helicobacter pylori Screening for Adolescents in Japan: Current Status, Challenges, and Implications: A Narrative Review.
Review in Helicobacter. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- AdolescentChildren (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundJapan has a high incidence of gastric cancer and is currently the only nation in which guidelines recommend Helicobacter pylori screening for adolescents. However, the implementation and implications of these initiatives have not been comprehensively characterized. The aim of this study was to provide a comprehensive overview of H. pylori screening programs for adolescents in Japan. MATERIALS AND
methodsA narrative review was conducted to summarize the studies on H. pylori screening among adolescents in Japan. Literature searches were performed in PubMed, Ichushi-Web, CiNii Research, and J-STAGE for articles published up to February 12, 2026. Studies that described H. pylori screening programs targeting adolescents in Japan were included. Data were extracted on study background and objectives, target age, screening methods, participation rates, infection prevalence, eradication regimens, eradication success rates, and adverse events.
resultsSeventeen studies met the inclusion criteria. Screening programs were typically local-government-led and school-based and primarily targeted junior high school students. A two-step diagnostic strategy employing noninvasive tests was commonly used. The median prevalence of H. pylori infection was 3.1%. Eradication regimens varied across programs; metronidazole- or vonoprazan-containing regimens generally showed higher eradication success rates than proton pump inhibitor-based clarithromycin-containing regimens, although cross-study comparisons should be interpreted cautiously because of heterogeneity. Adverse events were generally mild and predominantly gastrointestinal, and no serious complications were reported.
conclusionsLocal-government-led and school-based H. pylori screening among adolescents in Japan represents a feasible approach to the prevention of gastric cancer within a well-established school health system. The applicability of this strategy to other countries depends on several contextual factors, including the incidence of gastric cancer, health care infrastructure, and the presence of organized school health systems. In settings that lack these conditions, alternative community-based strategies may be required.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.