ReviewGalen medical journal2026
Transformative Approaches to Biomarker Assessment and Clinical Profiles in Pulmonary Hypertension Patients : Short title: Biomarker Assessment and Clinical Profiles in Pulmonary Hypertension Patients.
Review in Galen medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Pulmonary hypertension (PH) is a progressive disorder marked by elevated pulmonary arterial pressure, leading to right heart failure and high mortality. Emerging evidence links metabolic disturbances, renal dysfunction, and molecular dysregulation to PH pathogenesis. This study aimed to investigate biochemical and molecular biomarkers associated with PH, focusing on renal, metabolic, and vascular parameters. Materials and Methods: A hospital-based case-control study was conducted at Al-Sadr Teaching Hospital, Iraq, from January to June 2024. Sixty-two PH patients and 30 age- and sex-matched healthy controls were recruited. Fasting venous blood samples were analyzed for urea, creatinine, glucose, insulin, uric acid, troponin I, homocysteine, and KCNK3. Insulin resistance (IR) was estimated using HOMA-IR. Comparisons between groups were performed using independent t-tests, correlations via Pearson's coefficient, and diagnostic performance assessed using ROC curve analysis. Results: PH patients exhibited significantly elevated urea, creatinine, glucose, insulin, uric acid, homocysteine, and IR (P < 0.05) and reduced KCNK3 levels (P = 0.006) compared to controls. ROC analysis showed IR (AUC 0.903), homocysteine (AUC 0.762), and insulin (AUC 0.808) as effective discriminators of PH, whereas KCNK3 had limited diagnostic accuracy (AUC 0.350). Correlation analysis demonstrated positive associations between homocysteine and insulin/glucose, while KCNK3 inversely correlated with renal and metabolic parameters. Subgroup analysis indicated higher urea and glucose in male patients (P < 0.05). Conclusion: PH is associated with systemic metabolic dysregulation, renal impairment, and molecular alterations, including reduced KCNK3 and elevated homocysteine. Insulin resistance and homocysteine may serve as potential non-invasive biomarkers, highlighting the need for integrated biochemical and molecular assessment in PH management.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.