Evidence map›Paper›PMID 42605931›Full record

ArticleBiomedical chromatography : BMC2026

Metabolomics-Driven Bioactivity-Guided Isolation and Molecular Docking Reveal Antibreast Cancer Metabolome Heterogeneity in Polygonum spp.

Wenjing Zheng, Omar M Khattab, Qi Yuan, Yajie Wang, Feng Wei, Kaiyu Shen, Houwen Zhang, Xiaoqin Hu, Huiying Fu, Qiyang Shou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical chromatography : BMC, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wenjing ZhengJinhua Academy of, Zhejiang Chinese Medical University, Jinhua, China.ORCID https://orcid.org/0009-0004-5021-993X
Omar M KhattabJinhua Academy of, Zhejiang Chinese Medical University, Jinhua, China.
Qi YuanJinhua Academy of, Zhejiang Chinese Medical University, Jinhua, China.
Yajie WangJinhua Academy of, Zhejiang Chinese Medical University, Jinhua, China.
Feng WeiThe Second School of Clinical Medicine, Zhejiang Chinese Medical University, Zhejiang, Hangzhou, China.ORCID https://orcid.org/0000-0002-3933-5268
Kaiyu ShenThe Second School of Clinical Medicine, Zhejiang Chinese Medical University, Zhejiang, Hangzhou, China.
Houwen ZhangJinhua Academy of, Zhejiang Chinese Medical University, Jinhua, China.
Xiaoqin HuJinhua Academy of, Zhejiang Chinese Medical University, Jinhua, China.
Huiying FuThe Second School of Clinical Medicine, Zhejiang Chinese Medical University, Zhejiang, Hangzhou, China.ORCID https://orcid.org/0000-0002-1782-5258
Qiyang ShouJinhua Academy of, Zhejiang Chinese Medical University, Jinhua, China.

Funding

Jinhua Municipal Major Key Science and Technology Program Project 2024-3-015Jinhua Municipal Major Key Science and Technology Program Project 2026-3-101National Comprehensive Reform Demonstration Zone for Traditional Chinese Medicine (Zhejiang Province) Science and Technology Cooperation Project GZY-KJS-ZJ-2026-029National Natural Science Foundation of China 82174026National Natural Science Foundation of China 82274175National Natural Science Foundation of China 82474168Special Key Research Project of Scientific Research of the Affiliated Hospital of Zhejiang Chinese Medical University 2023FSYYZZ05Special Key Research Project of Scientific Research of the Affiliated Hospital of Zhejiang Chinese Medical University 2024FSYYZQ26
6 · The paper itself

Abstract

The rise of triple-negative breast cancer (TNBC) warrants the urgent need to identify novel therapies. Herein, untargeted metabolomics-guided isolation revealed the metabolome fingerprints of Polygonum bistorta (PB) and Polygonum viviparum (PV) in correlation with their TNBC inhibitory activity. Phytochemical analysis annotated 209 metabolites, with flavonoids (45 compounds) as the major class, followed by phenolic acids (25), tannins (24), and hydroxycinnamic acids (18). Multivariate data analysis identified chlorogenic acid, 6-O-galloylarbutin, and procyanidin B1 as key markers of PV, whereas naringenin-O-glucoside, catechin, and crataegunin D characterized PB. Among different polar extracts, ethyl acetate extract of PB (PB-EA) and the n-butanol extract of PV (PV-NB) exhibited the strongest cytotoxicity against 4T1 cells, with IC

Indexed as

Antineoplastic Agents, PhytogenicMetabolomeMetabolomicsPlant ExtractsPolygonumTriple Negative Breast NeoplasmsAnimalsCell Line, TumorFemaleHumansMiceMice, Inbred BALB CMolecular Docking SimulationAntineoplastic Agents, PhytogenicPlant Extractsbioassay‐guided isolationbreast cancermetabolomicsPolygonum bistorta LPolygonum viviparum L

Identifiers

PMID42605931
PMCPMC13479397

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.