Evidence map›Paper›PMID 42606739›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2026

Serotonin deficiency caused by inactivation of Tph2 in mice leads to widespread sex-dependent changes in cerebral oxidative metabolic activity.

Pilleriin Kupper, Margus Kanarik, Marianna Norden, Angelika G Schmitt-Böhrer, Ruth Shimmo, Klaus-Peter Lesch, Jaanus Harro

Abstract read
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In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pilleriin KupperDivision of Neuropsychopharmacology, Institute of Chemistry, University of Tartu, Ravila 14A Chemicum, 50411, Tartu, Estonia.ORCID http://orcid.org/0009-0001-3372-908X
Margus KanarikDivision of Neuropsychopharmacology, Institute of Chemistry, University of Tartu, Ravila 14A Chemicum, 50411, Tartu, Estonia.ORCID http://orcid.org/0000-0002-3326-5297
Marianna NordenSchool of Natural Sciences and Health, Tallinn University, Narva 25, 10120, Tallinn, Estonia.ORCID http://orcid.org/0000-0001-7308-3482
Angelika G Schmitt-BöhrerDepartment of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, Margarete-Höppel-Platz 1, 97080, Würzburg, Germany.ORCID http://orcid.org/0000-0002-2341-376X
Ruth ShimmoSchool of Natural Sciences and Health, Tallinn University, Narva 25, 10120, Tallinn, Estonia.ORCID http://orcid.org/0000-0002-0103-7337
Klaus-Peter LeschDivision of Molecular Psychiatry, Center of Mental Health, University Hospital Würzburg, Margarete-Höppel-Platz 1, 97080, Würzburg, Germany.ORCID http://orcid.org/0000-0001-8348-153X
Jaanus HarroDivision of Neuropsychopharmacology, Institute of Chemistry, University of Tartu, Ravila 14A Chemicum, 50411, Tartu, Estonia. jaanus.harro@ut.ee.ORCID https://orcid.org/0000-0002-4484-2096

Funding

Eesti Teadusagentuur PRG1213Horizon 2020 Framework Programme Grant No.728018 (Eat2beNICE)HORIZON EUROPE Framework Programme Grant No. 101086453 (Aqua-Synapse)Seventh Framework Programme Grant No.602805 (Aggressotype)
6 · The paper itself

Abstract

Tryptophan hydroxylase 2 (TPH2), the rate-limiting enzyme of serotonin synthesis in the CNS, has been associated with numerous behavioural traits and psychiatric disorders. Tph2 modified mice present altered sensitivity to stress, and excessively aggressive behaviour that develops even in female animals. We have measured histochemically the activity of cytochrome c oxidase (COX) in 106 brain regions in wildtype, Tph2 heterozygous and total knockout male and female mice (n=78). In addition to direct comparisons by sex and genotype, COX activity co-variation in putative aggression networks was examined. Overall, female mice have higher COX activity than males. In regions affected by Tph2 inactivation a consistent pattern emerged, where Tph2

Indexed as

Aggressive behaviourCytochrome oxidase histochemistryKO miceOxidative metabolismSerotonin deficiencySex differencesTryptophan hydroxylase 2

Identifiers

PMID42606739

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.