Evidence map›Paper›PMID 42608458›Full record

ArticleInternational journal of obesity (2005)2026

Normal dopamine uptake ratio on [

D L Marinus Oterdoom, Ellen Hendrikse, Anne H Mulder, Elise O M Broersen, Monique van der Weijden-Germann, Twan van Dalen, Chris W J van der Weijden, Nádia F Simões de Souza, Erik F J de Vries, J Marc C van Dijk and 1 more

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In one paragraph

Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

D L Marinus OterdoomDepartments of Neurosurgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. d.l.m.oterdoom@umcg.nl.ORCID http://orcid.org/0000-0002-9567-4256
Ellen HendrikseDepartments of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Anne H MulderDepartments of Neurosurgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Elise O M BroersenDepartments of Neurosurgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Monique van der Weijden-GermannDepartments of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Twan van DalenDepartments of Neurosurgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Chris W J van der WeijdenDepartments of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Nádia F Simões de SouzaDepartments of Neurosurgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Erik F J de VriesDepartments of Nuclear medicine and molecular imaging, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-6915-1590
J Marc C van DijkDepartments of Neurosurgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-0814-5680
André P van BeekDepartments of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-0335-8177

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesDopamine plays a key role in motivation and behavioral regulation and may influence eating behavior in obesity. Previous studies indicate altered dopamine receptor availability in obesity, but the role of presynaptic dopaminergic function remains unclear. This study employed [ SUBJECTS AND

methodsRoutine [18F]FDOPA PET/CT scans performed for the detection and follow-up of neuroendocrine tumors were reviewed. Striatal-to-occipital uptake ratios were used as an index of presynaptic dopaminergic tracer uptake after six hours of fasting. Individuals with normal weight (BMI ≤ 25) were compared with individuals with obesity (BMI ≥ 30) using multivariable regression analysis adjusted for age and sex. Sensitivity analyses included BMI modeled continuously and exploratory analyses of non-linear associations. A sensitivity analysis was performed in individuals with obesity class II (BMI 35-40).

resultsMedian striatal SUV ratios were 2.2 (IQR 0.4, n = 67) in participants with obesity and 2.3 (IQR 0.4, n = 67) in participants with normal weight. No significant differences were observed between groups in the striatum (p = 0.07), putamen (p = 0.17), or caudate nucleus (p = 0.14), including among individuals with BMI ≥ 35 kg/m². Continuous and multivariable analyses yielded consistent results.

conclusionThis study did not demonstrate significant differences in striatal [

Identifiers

PMID42608458

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.