Evidence map›Paper›PMID 42608587›Full record

ArticleNature cancer2026

Low-protein diet enhances antitumor immunity in pancreatic cancer through microbiota-derived UDP-galactose.

Yueying Chen, Fulin Nian, Shengdi Wu, Tianli Yuan, Yifan Ma, Junyang Cao, Yuxiao Zhang, Wenfeng Liu, Wenqing Tang, Danying Zhang and 9 more

Erratum issuedAbstract read
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In one paragraph

Article in Nature cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Yueying Chen *Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China.
Fulin Nian *Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China.
Shengdi Wu *Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China.
Tianli Yuan *Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yifan Ma *Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China.
Junyang CaoHealth Science Center, East China Normal University, Shanghai, China.
Yuxiao ZhangInstitutes of Biomedical Sciences and Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
Wenfeng LiuDepartment of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China.
Wenqing TangDepartment of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China.
Danying ZhangDepartment of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China.
Zi LiShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Wei LuShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0002-2391-5444
Fengwanni WangHealth Science Center, East China Normal University, Shanghai, China.
Xiulong XiaHealth Science Center, East China Normal University, Shanghai, China.
Zhanju LiuDepartment of Gastroenterology, The Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.ORCID http://orcid.org/0000-0002-0326-543X
Si ZhangNHC Key Laboratory of Glycoconjugates Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-5682-4995
Xizhong ShenDepartment of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China. shen.xizhong@zs-hospital.sh.cn.ORCID http://orcid.org/0000-0001-9328-5890
Xiaoming HuHealth Science Center, East China Normal University, Shanghai, China. xmhu@hsc.ecnu.edu.cn.
Ling DongDepartment of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China. dong.ling@zs-hospital.sh.cn.ORCID http://orcid.org/0000-0001-5995-7673

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81972234National Natural Science Foundation of China (National Science Foundation of China) 82170868National Natural Science Foundation of China (National Science Foundation of China) 82273027Natural Science Foundation of Chongqing (Natural Science Foundation of Chongqing Municipality) 2024NSCQ-MSX3956
6 · The paper itself

Abstract

Dietary interventions can influence cancer progression, yet the role of low-protein diets (LPDs) in pancreatic ductal adenocarcinoma (PDAC) immunotherapy is unclear. Here we show that an LPD suppresses PDAC progression in male mice by remodeling the gut microbiota and activating antitumor immunity. LPD promoted immune activation and drove an immunostimulatory tumor-associated macrophage phenotype. Microbiota depletion abolished these effects and fecal microbiota transplantation from LPD-fed donors transferred the protective phenotype to recipients. Mechanistically, LPD enriched Blautia coccoides, which produced uridine diphosphate (UDP)-galactose to activate the macrophage P2Y14R-STAT1 axis, inducing an immunostimulatory phenotype. Combining LPD, B. coccoides or UDP-galactose with anti-PD1 improved survival over anti-PD1 alone. In persons with advanced PDAC, reduced fecal B. coccoides and serum UDP-galactose correlated with poor outcomes. These findings establish that LPD reshapes the gut microbiota and metabolites to enhance antitumor immunity through the UDP-galactose-P2Y14R-STAT1 axis, offering a dietary strategy to improve PDAC immunotherapy.

Identifiers

PMID42608587

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.