ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2026
Plasma metabolomics in infancy reveals early signatures of a stringently-defined otitis-prone phenotype.
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Plasma metabolomics in infancy reveals early signatures of a stringently-defined otitis-prone phenotype.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
backgroundOtitis media is highly prevalent during early life, yet the molecular factors that predispose children to recurrent episodes are poorly defined. Metabolomics captures dynamic biochemical changes and may help identify pathways influencing otitis susceptibility. We examined whether longitudinal infant plasma metabolomic profiles were associated with development of stringently-defined otitis proneness in the Rochester Combined Cohort (RCC; Rochester, NY).
methodsGlobal plasma metabolomic profiling was performed in RCC samples collected between ~6 and 18 months of age using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Children were classified as stringently-defined otitis prone (sOP) if they experienced ≥3 acute otitis media (AOM) episodes within a 6-month period or ≥4 AOM episodes within a 12-month period during the first 3 years of life; all AOM episodes were tympanocentesis-confirmed. Generalized additive mixed models (GAMMs) assessed age-dependent differences in plasma metabolite levels between sOP and non-otitis-prone (nOP) children, adjusting for potential confounders.
resultsSeveral metabolites demonstrated age-related declines in lipid and amino acid pathways, with consistently lower metabolite trajectories in the sOP group. Compared with nOP children, sOP children exhibited significantly lower levels of 16 metabolites related to inflammatory lipid signaling, redox metabolism, and fatty acid metabolism (p < 4.4 × 10
conclusionChildren who subsequently met sOP criteria by age 3 years exhibited distinct plasma metabolomic signatures during infancy, suggesting altered immune-metabolic programming preceding recurrent otitis media. Longitudinal metabolomics provides a promising framework to identify biochemical mechanisms underlying otitis proneness.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.