ArticleFrontiers in endocrinology2026
Bilateral adrenal adenomas presenting with ACTH-independent Cushing's syndrome and primary aldosteronism: diagnostic insights from multi-steroid adrenal venous sampling.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Primary aldosteronism (PA) is the most prevalent cause of secondary hypertension (HTN), and adrenocorticotropic hormone (ACTH)-independent Cushing's syndrome (CS) represents a distinct form of adrenal-derived secondary HTN. Their coexistence resulting from aldosterone- and cortisol-producing adenomas (A/CPAs) is an extremely rare clinical entity. This is particularly true for the subtype characterized by bilateral adrenocortical adenomas, in which one adenoma predominantly secretes aldosterone (ALD) and the other predominantly secretes cortisol (COR), for which only limited clinical reports have been published to date. Case description: Both female patients were diagnosed with PA and concurrent ACTH-independent CS. Abdominal computed tomography (CT) revealed bilateral adrenal space-occupying lesions. Adrenal venous sampling (AVS) was subsequently performed using 17α-hydroxyprogesterone (17-OHP), androstenedione (ASD), dehydroepiandrosterone (DHEA) as the reference hormone, which demonstrated lateralized dominance of COR and ALD secretion from opposite adrenal glands. Corresponding clinical features confirmed the diagnosis of A/CPAs in both cases. One patient underwent laparoscopic left adrenal CPA resection, while the other underwent laparoscopic right adrenal CPA resection. Following laparoscopic resection of the CPA in both patients, postoperative COR levels declined, consistent with surgical remission. Spironolactone therapy was initiated. Pathological examination confirmed adrenocortical adenoma. Immunohistochemistry (IHC) showed strong positive expression of CYP11B1 (11β-hydroxylase) and weak expression of CYP11B2 (ALD synthase). Their conditions have remained well controlled to date. Conclusions: In patients with bilateral adrenal adenomas and concurrent PA and ACTH-independent COR excess, imaging alone may fail to identify the functional source of hormone excess. Multi-steroid adrenal venous sampling demonstrated opposing ALD and COR dominance from contralateral adrenal glands, guiding targeted resection of the COR-dominant lesion and postoperative medical control of residual ALD excess. These cases support multi-steroid AVS for individualized adrenal-sparing management.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.