SynthesisFrontiers in medicine2026
Risk factors for vertebral fractures in postmenopausal women: a meta-analysis.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Vertebral fractures are the most common osteoporotic fractures in postmenopausal women and are strongly associated with higher morbidity, lower quality of life, and higher risk of death. Identifying risk factors for vertebral fractures in postmenopausal women is essential for early prevention and intervention. The aim of this study was to systematically assess and quantify the risk factors for vertebral fractures in postmenopausal women by meta-analysis. Methods: We conducted a comprehensive search in PubMed, Embase, Web of Science, and Cochrane Library databases to include all observational studies reporting risk factors for vertebral fractures in postmenopausal women. The search was conducted from the date of database creation to April 20, 2025, Study screening, data extraction, and quality assessment were performed by two independent reviewers, and study quality was assessed using the Newcastle-Ottawa scale. Data were analyzed using Stata15 software. Results: A total of 11 studies involving 7,605 participants were included. The meta-analysis showed that advanced age [odds ratio (OR) = 1.07, 95% confidence interval (CI): 1.03-1.12], higher body mass index (BMI; OR = 1.07, 95% CI: 1.01-1.14), previous fracture (OR = 1.78, 95% CI: 1.29-2.45), low lumbar-spine bone mineral density (BMD; OR = 1.55, 95% CI: 1.27-1.89), glucocorticoid use (OR = 2.34, 95% CI: 1.34-4.09), and rheumatoid arthritis (OR = 2.99, 95% CI: 1.38-6.45) were associated with a higher likelihood of vertebral fracture in postmenopausal women. Conclusion: This meta-analysis showed that risk factors for vertebral fracture in postmenopausal women include age over 60 years, higher body mass index, history of previous fracture, low lumbar bone density, glucocorticoid use, and rheumatoid arthritis. These factors significantly increase the risk of vertebral fractures. Therefore, early screening and intervention in these high-risk groups is warranted to reduce the incidence of vertebral fractures and to provide more individualized prevention and treatment strategies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.