Evidence map›Paper›PMID 42609639›Full record

ArticleMedComm2026

Lcn2 Promotes Ferroptosis in Intracerebral Hemorrhage by Targeting Keap1 Tyr572 and Restricting Nrf2 Activation.

Ya-Nan Dou, Hongkang Hu, Qinghua Li, Guangming Wang, Lijun Hou, Junbin Liu, Buyi Zheng, Ying Li, Guohan Hu, Zhou Fei and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ya-Nan DouDepartment of Neurosurgery Xijing Hospital Air Force Military Medical University Xi'an Shaanxi China.
Hongkang HuDepartment of Neurosurgery Changzheng Hospital Naval Medical University Shanghai China.
Qinghua LiDepartment of Pediatrics Shanghai Ninth People's Hospital Shanghai JiaoTong University School of Medicine Shanghai China.
Guangming WangDepartment of Neurosurgery Changzheng Hospital Naval Medical University Shanghai China.
Lijun HouDepartment of Neurosurgery Changzheng Hospital Naval Medical University Shanghai China.
Junbin LiuDepartment of Orthopedics Changzheng Hospital Naval Medical University Shanghai China.
Buyi ZhengDepartment of Neurosurgery Wenzhou People's Hospital Wenzhou Zhejiang China.
Ying LiDepartment of Pathology Changzheng Hospital Naval Medical University Shanghai China.
Guohan HuDepartment of Neurosurgery Changzheng Hospital Naval Medical University Shanghai China.
Zhou FeiDepartment of Neurosurgery Xijing Hospital Air Force Military Medical University Xi'an Shaanxi China.
Xia LiDepartment of Neurosurgery Xijing Hospital Air Force Military Medical University Xi'an Shaanxi China.
Li WangDepartment of Neurosurgery Xijing Hospital Air Force Military Medical University Xi'an Shaanxi China.
Jialiang WeiDepartment of Neurosurgery Xijing Hospital Air Force Military Medical University Xi'an Shaanxi China.
Lei JiangDepartment of Neurosurgery Changzheng Hospital Naval Medical University Shanghai China.
Xiaowei FeiDepartment of Neurosurgery Xijing Hospital Air Force Military Medical University Xi'an Shaanxi China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferroptosis is a major driver of neuronal injury after intracerebral hemorrhage (ICH). Lipocalin‑2 (Lcn2), an iron‑binding transport protein, modulates neuronal iron homeostasis and has been reported to exert both neurotoxic and neuroprotective actions. The precise contribution of Lcn2 to ferroptosis following ICH remains unresolved. Here, it is found that Lcn2 concentrations were significantly higher in hematoma than in arterial blood from the same patients. Proteomics and inflammation‑array data converged on ferroptosis and the Nrf2-Keap1 axis as key pathways altered in Lcn2

Indexed as

ferroptosisintracerebral hemorrhagelipocalin‐2nuclear factor erythroid 2‐related factor 2oxidative stress

Identifiers

PMID42609639
PMCPMC13478554

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.