Evidence map›Paper›PMID 42609792›Full record

ArticleERJ open research2026

Association of PiSlope with lung function decline in individuals with preserved spirometry: a prospective cohort study.

Suyin Huang, Fan Wu, Yuheng Wang, Kunning Zhou, Qi Wan, Gaoying Tang, Zhishan Deng, Fangyan Wu, Cuiqiong Dai, Lifei Lu and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Suyin HuangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, National Center for Respiratory Medicine and Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0009-0003-7777-3415
Fan WuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, National Center for Respiratory Medicine and Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0003-0720-4674
Yuheng WangHangzhou Smart Intelligent Co. Ltd, Hangzhou, China.
Kunning ZhouState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, National Center for Respiratory Medicine and Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0002-2805-9317
Qi WanState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, National Center for Respiratory Medicine and Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0003-1277-0910
Gaoying TangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, National Center for Respiratory Medicine and Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhishan DengState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, National Center for Respiratory Medicine and Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0009-0001-3836-7583
Fangyan WuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, National Center for Respiratory Medicine and Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Cuiqiong DaiState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, National Center for Respiratory Medicine and Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0003-2439-3200
Lifei LuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, National Center for Respiratory Medicine and Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xiaohui WuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, National Center for Respiratory Medicine and Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xiaoyu WangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, National Center for Respiratory Medicine and Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Junfeng LinState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, National Center for Respiratory Medicine and Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Guannan CaiState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, National Center for Respiratory Medicine and Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xianliang ZengState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, National Center for Respiratory Medicine and Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Ping WangHangzhou Smart Intelligent Co. Ltd, Hangzhou, China.
Changli YangWengyuan County People's Hospital, Shaoguan, China.
Shengtang ChenWengyuan County People's Hospital, Shaoguan, China.
Yongqing HuangLianping County People's Hospital, Heyuan, China.
Shuqing YuLianping County Second People's Hospital, Heyuan, China.
Yu DengDepartment of Radiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Pixin RanState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, National Center for Respiratory Medicine and Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0003-1722-8637
Yumin ZhouState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, National Center for Respiratory Medicine and Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0002-0555-8391

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Airway remodelling precedes airflow obstruction in COPD. Pi10 assumes a consistent fixed slope between airway wall thickness and lumen perimeter across individuals. PiSlope comprehensively quantifies airway wall thickening, which is associated with increased acute exacerbation and mortality risk. Whether PiSlope is associated with respiratory prognosis in participants with preserved spirometry is unknown. Methods: Participants with preserved spirometry with complete baseline questionnaires, spirometry and chest computed tomography were enrolled from a 3-year prospective Early Chronic Obstructive Pulmonary Disease (ECOPD) cohort study and divided into four groups by PiSlope quartile (Q) (Q1: PiSlope ≥0.4946, Q2: 0.4550≤ PiSlope <0.4946, Q3: 0.4149≤ PiSlope <0.4550, Q4: PiSlope <0.4149). Clinical outcomes included lung function decline and risk of airflow obstruction progression. Results: 1140 participants with preserved spirometry were included and 1067 (93.6%) completed at least one follow-up lung function assessment. One standard deviation decrease in PiSlope was associated with accelerated decline in pre-bronchodilator forced expiratory volume in 1 s (FEV Conclusion: Lower PiSlope was associated with faster lung function decline and increased airflow obstruction risk in participants with preserved spirometry, but the association between PiSlope and progression to airflow obstruction was not significant after adjustment.

Identifiers

PMID42609792
PMCPMC13478871

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.