Evidence map›Paper›PMID 42609989›Full record

ArticleChemical science2026

A head-to-tail dimeric J-aggregate probe for rapid and ratiometric imaging of mitochondrial 5-HT

Chenming Chan, Yujie Han, Yu-Fei Song, Qi-Wei Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chenming ChanSchool of Chemistry and Molecular Engineering, East China Normal University Dongchuan Road 500 Shanghai 200241 China qwzhang@chem.ecnu.edu.cn.
Yujie HanSchool of Chemistry and Molecular Engineering, East China Normal University Dongchuan Road 500 Shanghai 200241 China qwzhang@chem.ecnu.edu.cn.
Yu-Fei SongSchool of Chemistry and Molecular Engineering, East China Normal University Dongchuan Road 500 Shanghai 200241 China qwzhang@chem.ecnu.edu.cn.
Qi-Wei ZhangSchool of Chemistry and Molecular Engineering, East China Normal University Dongchuan Road 500 Shanghai 200241 China qwzhang@chem.ecnu.edu.cn.ORCID https://orcid.org/0000-0003-1527-0559

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The precise role of 5-hydroxytryptamine (5-HT) in depression remains mechanistically unresolved. While synaptic deficits dominate the monoamine hypothesis, emerging evidence points to mitochondrial dysfunction as a key factor. However, progress has been hindered by the lack of tools capable of directly, specifically, and quantitatively tracking real-time 5-HT dynamics within mitochondria. Here, we present FPY, a ratiometric fluorescent probe featuring unique head-to-tail dimeric J-aggregation

Identifiers

PMID42609989
PMCPMC13479796

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.