Evidence map›Paper›PMID 42610070›Full record

ArticleSexual medicine2026

SEXATURN: sexual function of patients with Turner syndrome compared to that of women with premature ovarian insufficiency.

Eugénie de Paillette, Daphné Karila, Alexandra Rousseau, Emma Dubost, Tiphaine Meykiechel, Sophie Lamothe, Camille Vatier, Sylvie Jaillard, Mariana Nedelcu, Nathalie Bourcigaux and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sexual medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05223621 (Sexuality and Sexual Quality of Life in Adult Patients With Turner Syndrome), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05223621 unknown statusnot on this map

Sexuality and Sexual Quality of Life in Adult Patients With Turner Syndrome (TS) Compared With Patients With Primary Ovarian Insufficiency and Normal Karyotype

TypeobservationalSponsorAssistance Publique - Hôpitaux de ParisRan2022 to 2022Enrolled300ConditionsTurner Syndrome, Primary Ovarian Insufficiency
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eugénie de PailletteCentre of rare diseases CRESCENDO, Endocrine Unit, Hôpital Saint-Antoine, Assistance-Publique Hôpitaux de Paris, Endo-ERN Network, 75012 Paris, France.
Daphné KarilaCentre of rare diseases CRESCENDO, Endocrine Unit, Hôpital Saint-Antoine, Assistance-Publique Hôpitaux de Paris, Endo-ERN Network, 75012 Paris, France.
Alexandra RousseauPlateforme de Recherche Clinique de l'Est Parisien, Unité de Recherche Clinique (URC)-Est, Hôpital Saint-Antoine, Assistance-Publique Hôpitaux de Paris, 75012 Paris, France.
Emma DubostCentre of rare diseases CRESCENDO, Endocrine Unit, Hôpital Saint-Antoine, Assistance-Publique Hôpitaux de Paris, Endo-ERN Network, 75012 Paris, France.
Tiphaine MeykiechelCentre of rare diseases CRESCENDO, Endocrine Unit, Hôpital Saint-Antoine, Assistance-Publique Hôpitaux de Paris, Endo-ERN Network, 75012 Paris, France.
Sophie LamotheCentre of rare diseases CRESCENDO, Endocrine Unit, Hôpital Saint-Antoine, Assistance-Publique Hôpitaux de Paris, Endo-ERN Network, 75012 Paris, France.
Camille VatierCentre of rare diseases CRESCENDO, Endocrine Unit, Hôpital Saint-Antoine, Assistance-Publique Hôpitaux de Paris, Endo-ERN Network, 75012 Paris, France.ORCID https://orcid.org/0000-0001-8342-1596
Sylvie JaillardUniversity of Rennes, CHU Rennes, Inserm, EHESP, Irset and Cytogenetic and cellular biology department (Institut de Recherche en Santé, Environnement et Travail) -UMR_S1085, Service de Cytogénétique et Biologie Cellulaire, 35000 Rennes, France.ORCID https://orcid.org/0000-0002-0593-0261
Mariana NedelcuCentre of rare diseases CRESCENDO, Endocrine Unit, Hôpital Saint-Antoine, Assistance-Publique Hôpitaux de Paris, Endo-ERN Network, 75012 Paris, France.
Nathalie BourcigauxCentre of rare diseases CRESCENDO, Endocrine Unit, Hôpital Saint-Antoine, Assistance-Publique Hôpitaux de Paris, Endo-ERN Network, 75012 Paris, France.ORCID https://orcid.org/0000-0002-0606-9450
Bruno DonadilleCentre of rare diseases CRESCENDO, Endocrine Unit, Hôpital Saint-Antoine, Assistance-Publique Hôpitaux de Paris, Endo-ERN Network, 75012 Paris, France.
Sophie Christin-MaitreCentre of rare diseases CRESCENDO, Endocrine Unit, Hôpital Saint-Antoine, Assistance-Publique Hôpitaux de Paris, Endo-ERN Network, 75012 Paris, France.ORCID https://orcid.org/0000-0002-6057-6840

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Reduced sexual activity has been reported in women with Turner syndrome (TS), a chromosomal disorder frequently associated with premature ovarian insufficiency (POI), but data on sexual function and its qualitative aspects remain limited. Furthermore, few studies have compared sexual function of women with TS to that of women with POI from other etiologies (non-TS POI). Our aim was to assess sexual function in women with TS and compare it to that of women with non-TS POI, and to evaluate whether sexual dysfunction in TS is related to different comorbidities. Methods: SEXATURN is a monocentric, cross-sectional study (NCT05223621) conducted at a French reference center for rare endocrine diseases. We included women aged 18-50 years with TS or non-TS POI. Sexual function was assessed using the abbreviated Female Sexual Function Index (FSFI-6). Clinical data were collected through questionnaires and electronic medical records. The primary outcome was the prevalence of impaired sexual function (FSFI-6 < 19). Secondary outcomes included comparison of FSFI-6 scores between TS and non-TS POI, FSFI-6 scores among sexually active patients and identification of factors associated with sexual dysfunction. Results: A total of 205 women were included (99 with TS, 106 with non-TS POI). Impaired sexual function was observed in 49.5% of women with TS and 43.4% of women with non-TS POI, without significant difference ( Discussion: Strengths are a well-phenotyped cohort from a reference center, the use of a validated questionnaire and high response rates. Limitations include intrinsic limits of the FSFI-6, which does not assess distress or broader sexual experiences. SEXATURN study shows that women with TS exhibit reduced sexual activity but similar rates of impaired sexual function compared to women with non-TS POI. Being in a relationship is a protective factor. Our findings support the need of sexual and psychological care into multidisciplinary management of patients with TS. Trial registration: ClinicalTrial.gov (NCT05223621) registration date January 24, 2022 and date of enrolment of the first subject December 02, 2022.

Indexed as

female sexual functionfemale sexual function indexFSFI-6physiologicalprimary ovarian insufficiencysexual dysfunctionsexualityTurner syndrome

Identifiers

PMID42610070
PMCPMC13480476

What Socratic holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.