Evidence map›Paper›PMID 42610081›Full record

ArticleRSC advances2026

Quinazolinone-triazole hybrids as multi-target-directed ligands for Alzheimer's disease: discovery of potent and selective MAO-B inhibitors with cholinesterase modulating activity.

Wagdy M Eldehna, Ashraf K El-Damasy, Jaeyeop Lim, Salma M Hefny, Tarfah Al-Warhi, Amal S Elgohary, Anwar A El-Hamaky, Man-Jeong Paik, Mohamed R Elnagar, Diaaeldin M Elimam and 3 more

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wagdy M EldehnaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University P. O. Box 33516 Kafrelsheikh Egypt wagdy2000@gmail.com.ORCID https://orcid.org/0000-0001-6996-4017
Ashraf K El-DamasyDepartment of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University Mansoura 35516 Egypt ph_karem2000@man.edu.eg.
Jaeyeop LimCollege of Pharmacy, Sunchon National University Suncheon 57922 Republic of Korea hoon@sunchon.ac.kr.
Salma M HefnyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University Tanta 31527 Egypt.ORCID https://orcid.org/0009-0004-8313-7586
Tarfah Al-WarhiDepartment of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University P.O. Box 84428 Riyadh 11671 Saudi Arabia.
Amal S ElgoharyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University Tanta 31527 Egypt.ORCID https://orcid.org/0009-0003-4462-574X
Anwar A El-HamakyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University Tanta 31527 Egypt.ORCID https://orcid.org/0000-0001-8887-2310
Man-Jeong PaikCollege of Pharmacy, Sunchon National University Suncheon 57922 Republic of Korea hoon@sunchon.ac.kr.
Mohamed R ElnagarDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University Cairo 11823 Egypt.ORCID https://orcid.org/0000-0003-0434-2369
Diaaeldin M ElimamDepartment of Pharmacognosy, Faculty of Pharmacy, Kafrelsheikh University Kafrelsheikh 33516 Egypt.
Yasser M OmarInstitute of Cancer Therapeutics, University of Bradford BD7 1DP UK.
Hoon KimCollege of Pharmacy, Sunchon National University Suncheon 57922 Republic of Korea hoon@sunchon.ac.kr.ORCID https://orcid.org/0000-0002-7203-3712
Haytham O TawfikDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University Tanta 31527 Egypt.ORCID https://orcid.org/0000-0001-6455-5716

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new series of quinazolinone-triazole hybrids (QTHs, 5a-n) was designed, synthesized, and evaluated as potential multi-target-directed ligands for Alzheimer's disease. All synthesized compounds were screened against human monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). The obtained results revealed pronounced selectivity toward MAO-B, with IC

Identifiers

PMID42610081
PMCPMC13480371

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.