Evidence map›Paper›PMID 42610249›Full record

ArticleCirculation2026

Myeloid Cell Expansion Propels Right Ventricular Dysfunction in HFpEF Through Sterile Inflammation.

Lara Jaeschke, Ceren Koçana, Alexandra Maria Chitroceanu, Annika Winkler, Hannah Kleitke, Pauline Fahjen, Justus Kamp, David Faidel, Erik Asmus, Martin Meiser and 25 more

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In one paragraph

Article in Circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors.

Lara JaeschkeDepartment of Cardiothoracic and Vascular Surgery (L.J., C.K., A.W., H.K., J.K., D.F., E.A., M.M., L.A.v.d.O., K.B., J.L.G., N.B., N.H., J.G.), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.ORCID 0009-0004-1847-5378
Ceren KoçanaDepartment of Cardiothoracic and Vascular Surgery (L.J., C.K., A.W., H.K., J.K., D.F., E.A., M.M., L.A.v.d.O., K.B., J.L.G., N.B., N.H., J.G.), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.ORCID 0000-0001-5863-2447
Alexandra Maria ChitroceanuCampus Virchow Klinikum (A.M.C., D.Z., K.F., E.R., S.v.L., C.O., F.E.), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.
Annika WinklerDepartment of Cardiothoracic and Vascular Surgery (L.J., C.K., A.W., H.K., J.K., D.F., E.A., M.M., L.A.v.d.O., K.B., J.L.G., N.B., N.H., J.G.), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.ORCID 0009-0007-9434-3862
Hannah KleitkeDepartment of Cardiothoracic and Vascular Surgery (L.J., C.K., A.W., H.K., J.K., D.F., E.A., M.M., L.A.v.d.O., K.B., J.L.G., N.B., N.H., J.G.), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.ORCID 0009-0006-9991-6044
Pauline FahjenProteomics Platform, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany (P.F., P.M.).ORCID 0000-0002-5015-0643
Justus KampDepartment of Cardiothoracic and Vascular Surgery (L.J., C.K., A.W., H.K., J.K., D.F., E.A., M.M., L.A.v.d.O., K.B., J.L.G., N.B., N.H., J.G.), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.ORCID 0009-0009-4088-3796
David FaidelDepartment of Cardiothoracic and Vascular Surgery (L.J., C.K., A.W., H.K., J.K., D.F., E.A., M.M., L.A.v.d.O., K.B., J.L.G., N.B., N.H., J.G.), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.ORCID 0000-0001-9606-9595
Erik AsmusDepartment of Cardiothoracic and Vascular Surgery (L.J., C.K., A.W., H.K., J.K., D.F., E.A., M.M., L.A.v.d.O., K.B., J.L.G., N.B., N.H., J.G.), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.ORCID 0000-0003-4740-7724
Martin MeiserDepartment of Cardiothoracic and Vascular Surgery (L.J., C.K., A.W., H.K., J.K., D.F., E.A., M.M., L.A.v.d.O., K.B., J.L.G., N.B., N.H., J.G.), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.
Efstathios G StamatiadesCampus Virchow Klinikum, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin (L.J., C.K., A.M.C., A.W., H.K., J.K., D.F., E.A., M.M., E.G.S., K.W.H., D.Z., P.-L.P., L.A.v.d.O., K.B., S.S., J.L.G., K.F., E.R., N.B., N.H., P.M., F.E., J.G.), Germany.ORCID 0000-0002-2785-9005
Karolin W HublitzCampus Virchow Klinikum, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin (L.J., C.K., A.M.C., A.W., H.K., J.K., D.F., E.A., M.M., E.G.S., K.W.H., D.Z., P.-L.P., L.A.v.d.O., K.B., S.S., J.L.G., K.F., E.R., N.B., N.H., P.M., F.E., J.G.), Germany.ORCID 0000-0003-4840-4496
Veronika ZachDZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Germany (L.J., C.K., A.M.C., H.K., J.K., D.F., E.A., V.Z., D.Z., P.-L.P., L.A.v.d.O., K.B., S.S., J.L.G., K.F. G.G.S., S.v.L., N.B., C.O., N.H., P.M., F.E., W.M.K., J.G.).
Lucie KretzlerDepartment of Internal Medicine and Cardiology, Campus Virchow Klinikum (V.Z., L.K.), Charité-Universitätsmedizin Berlin, Germany.
Daniela ZurkanCampus Virchow Klinikum (A.M.C., D.Z., K.F., E.R., S.v.L., C.O., F.E.), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.ORCID 0009-0000-1016-439X
Paul-Lennard PerretInstitute of Physiology (L.J., C.K., A.W., H.K., J.K., D.F., E.A., M.M., P.-L.P., L.A.v.d.O., S.S., J.L.G., N.H., W.M.K., J.G.), Germany.
Leonardo A von der OheDepartment of Cardiothoracic and Vascular Surgery (L.J., C.K., A.W., H.K., J.K., D.F., E.A., M.M., L.A.v.d.O., K.B., J.L.G., N.B., N.H., J.G.), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.ORCID 0009-0004-7626-3146
Kai BeckschulteDepartment of Cardiothoracic and Vascular Surgery (L.J., C.K., A.W., H.K., J.K., D.F., E.A., M.M., L.A.v.d.O., K.B., J.L.G., N.B., N.H., J.G.), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.
Szandor SimmonsInstitute of Physiology (L.J., C.K., A.W., H.K., J.K., D.F., E.A., M.M., P.-L.P., L.A.v.d.O., S.S., J.L.G., N.H., W.M.K., J.G.), Germany.ORCID 0000-0002-5309-9863
Jonathan L GillanDepartment of Cardiothoracic and Vascular Surgery (L.J., C.K., A.W., H.K., J.K., D.F., E.A., M.M., L.A.v.d.O., K.B., J.L.G., N.B., N.H., J.G.), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.ORCID 0000-0002-9017-253X
Kristina FranzCampus Virchow Klinikum (A.M.C., D.Z., K.F., E.R., S.v.L., C.O., F.E.), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.
Lina AlasfarDepartments of Cardiology (L.A., B.P.), Germany.
Virginia S HahnDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (V.S.H., K.S.).ORCID 0000-0002-0578-2668
Kavita SharmaDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (V.S.H., K.S.).ORCID 0000-0002-3012-1765
Edwardo ReynoldsCampus Virchow Klinikum (A.M.C., D.Z., K.F., E.R., S.v.L., C.O., F.E.), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.ORCID 0000-0002-5148-1479
Gabriele G SchiattarellaDepartment of Cardiology, Angiology and Intensive Care Medicine (G.G.S.), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.ORCID 0000-0002-7582-7171
Sophie van LinthoutCampus Virchow Klinikum (A.M.C., D.Z., K.F., E.R., S.v.L., C.O., F.E.), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.ORCID 0000-0002-7581-7870
Burkert PieskeDepartments of Cardiology (L.A., B.P.), Germany.
Niklas BeyhoffDepartment of Cardiothoracic and Vascular Surgery (L.J., C.K., A.W., H.K., J.K., D.F., E.A., M.M., L.A.v.d.O., K.B., J.L.G., N.B., N.H., J.G.), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.ORCID 0000-0001-9140-2336
Christiane OttCampus Virchow Klinikum (A.M.C., D.Z., K.F., E.R., S.v.L., C.O., F.E.), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.ORCID 0000-0002-3199-0655
Niklas HegemannDepartment of Cardiothoracic and Vascular Surgery (L.J., C.K., A.W., H.K., J.K., D.F., E.A., M.M., L.A.v.d.O., K.B., J.L.G., N.B., N.H., J.G.), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.ORCID 0000-0002-2898-0798
Philipp MertinsCampus Virchow Klinikum, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin (L.J., C.K., A.M.C., A.W., H.K., J.K., D.F., E.A., M.M., E.G.S., K.W.H., D.Z., P.-L.P., L.A.v.d.O., K.B., S.S., J.L.G., K.F., E.R., N.B., N.H., P.M., F.E., J.G.), Germany.ORCID 0000-0002-2245-528X
Frank EdelmannCampus Virchow Klinikum (A.M.C., D.Z., K.F., E.R., S.v.L., C.O., F.E.), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.ORCID 0000-0003-4401-5936
Wolfgang M Kuebler *Institute of Physiology (L.J., C.K., A.W., H.K., J.K., D.F., E.A., M.M., P.-L.P., L.A.v.d.O., S.S., J.L.G., N.H., W.M.K., J.G.), Germany.ORCID 0000-0003-4100-2961
Jana Grune *Department of Cardiothoracic and Vascular Surgery (L.J., C.K., A.W., H.K., J.K., D.F., E.A., M.M., L.A.v.d.O., K.B., J.L.G., N.B., N.H., J.G.), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.ORCID 0000-0001-6209-7416

Funding

Analysis of Single Cell Transcriptomics and Cardiac Metabolism in Heart Failure with Preserved Ejection FractionK23HL166770 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Virginia Shalkey Hahn · 2023 to 2026
$792k
NHLBI NIH HHS K23 HL166770
6 · The paper itself

Abstract

backgroundThe role of leukocytes in the pathogenesis of right ventricular (RV) dysfunction (RVD) associated with heart failure with preserved ejection fraction (HFpEF) remains poorly defined, partially due to the lack of suitable small animal models. Here, we followed a translational research approach by establishing a murine HFpEF model developing manifest RVD and analyzed human HFpEF cohorts to study the mechanistic link between leukocytes and RVD in HFpEF.

methodsYoung (<20-week-old) and aged (>80-week-old) male and female C57BL/6J mice were divided into 4 experimental groups: chow, HFpEF (L-NAME [Nω-nitro-L-arginine methyl ester] plus a high-fat diet), chronic hypoxia (10% O

resultsRV-HFpEF resulted in left ventricular diastolic dysfunction, indicated by increased E/E' ratio, reduced global longitudinal peak strain, smaller end-diastolic diameters, and increased isovolumetric relaxation time compared with chow. RV-HFpEF animals developed RV hypertrophy and RVD, evident as increased Fulton index as well as elevated RV systolic pressure and reduced tricuspid annular plane systolic excursion, respectively. Total leukocyte, monocyte, and macrophage counts were elevated in RV tissue from RV-HFpEF mice compared with RV tissue from chow mice and left ventricular tissue from young and aged RV-HFpEF animals. These findings were confirmed by unbiased proteomic analyses of RV tissue from RV-HFpEF mice, demonstrating an increased abundance of proteins involved in activation of the innate immune system, macrophage chemotaxis, and leukocyte migration when compared with left ventricular tissue and the other experimental groups. Fate-mapping experiments revealed that recruited monocyte-derived macrophages became the main source of total cardiac macrophages in RV tissue from RV-HFpEF mice. Depletion of myeloid cells was associated with lower RVSP profiles in RV-HFpEF mice compared with controls. In RV biopsies from patients with HFpEF, we found increased expression of adhesion molecules, fibrotic markers, and inflammatory transcripts, as well as an association between RVD and CD68

conclusionsWe demonstrate that dysregulated myeloid cell dynamics are associated with, and directly contribute to, the pathogenesis of RVD associated with HFpEF in humans and mice.

Indexed as

Heart FailureInflammationMyeloid CellsStroke VolumeVentricular Dysfunction, RightAnimalsDisease Models, AnimalFemaleHumansMacrophagesMaleMiceMice, Inbred C57BLVentricular Function, RightVentricular Remodelingheart failureheart ventriclesinflammationmacrophagesmyeloid cells

Identifiers

PMID42610249
PMCPMC7619445

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