ArticleJournal of molecular histology2026
Circ_0070190 suppresses the malignant progression of cervical cancer by sponging miR-587.
Article in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
The purpose of this study is to explore the function of circ_0070190 in cervical cancer (CC) as well as its regulatory mechanism through sponging miR-587. RT-qPCR was applied to detect the expression of circ_0070190 and miR-587 in CC tissues, corresponding adjacent normal tissues, and CC cell lines. The impact of circ_0070190 on the proliferative capacity of CC cells was evaluated using CCK-8, while the Transwell assay was utilized to determine its effect on cell migration and invasion. The targeted binding relationship between circ_0070190 and miR-587 was confirmed by dual luciferase reporter gene assay and RNA co-immunoprecipitation (RIP) assay. The expression of circ_0070190 in CC tissues was markedly downregulated compared with that in adjacent normal tissues. Additionally, low expression of circ_0070190 were associated with positive lymph node metastasis and higher FIGO stage, and the Kaplan-Meier curve and Cox analysis indicated that low circ_0070190 level predicted a shorter survival period of 5 years for CC patients. Overexpression of circ_0070190 remarkably suppressed the proliferation, migration, and invasion of CC cells. Importantly, miR-587 is a direct target of circ_0070190, the suppressive effect of circ_0070190 was abrogated by miR-587 mimic. Circ_0070190 might be a prognostic marker for CC and exerts an inhibitory effect on the malignant progression by sponging miR-587. The circ_0070190/miR-587 regulatory axis may offer a potential novel target for the targeted therapy of CC.
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