In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
18 authors.
Pakhi BirlaSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21205.ORCID 0000-0002-7252-5717 Lansaol YangSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21205.
Wanting ShanSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21205.
Sakura MinamisawaDepartment of Pathology and Oncology, Faculty of Medicine, Juntendo University, Tokyo 113-842, Japan.ORCID 0009-0002-6204-7413 Omkar DhaygudeDepartment of Mechanical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218.
Haritha ManojSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21205.
Jacqueline FerriSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21205.ORCID 0009-0009-4340-6936 Andrew NorthcuttSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21205.ORCID 0000-0001-5118-1217 Hongni FanSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21205.
Hadley BeauregardDepartment of Medicine, Division of Infectious Disease, Johns Hopkins University, Baltimore, MD 21205.
Kellie N SmithSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21205.
Fyza Y ShaikhSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21205.ORCID 0000-0001-7839-8483 Cynthia L SearsBloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine, Baltimore, MD 21205.ORCID 0000-0003-4059-1661 Drew M PardollSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21205.ORCID 0000-0001-6215-1013 Franck HousseauSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21205.ORCID 0000-0002-7028-3953 Funding
Commonwealth Foundation for Cancer Research Foundation CommonwealthJHU | Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University | Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University (Bloomberg ~ Kimmel Institute for Cancer Immunotherapy) BKI
6 · The paper itselfAbstract
Mucosal-associated invariant T (MAIT) cells are innate-like T cells capable of MR1-dependent immune surveillance, but how intratumoral bacteria modulate MR1 expression in human lung tumors remains unclear. We studied intratumoral MAIT cells from paired single-cell RNA and TCR sequencing datasets of tumor-infiltrating CD3 T cells isolated from non-small cell lung cancer tumors in patients receiving neoadjuvant PD-1 blockade therapy. MAIT cells were subclustered to identify conventional MAIT-associated TCR clonotypes, which were then used to examine how bacterial exposure impacts cell-surface MR1 expression and downstream MAIT TCR activation. We found that select intratumoral
Indexed as
Carcinoma, Non-Small-Cell LungEnterococcusHistocompatibility Antigens Class ILung NeoplasmsMinor Histocompatibility AntigensMucosal-Associated Invariant T CellsReceptors, Antigen, T-CellRiboflavinHumansLymphocyte ActivationRibitolUracil5-(2-oxopropylideneamino)-6-d-ribitylaminouracilHistocompatibility Antigens Class IMinor Histocompatibility AntigensMR1 protein, humanReceptors, Antigen, T-CellRibitolRiboflavinUracilEnterococcusMAITMR1tumor microbiome
Identifiers
PMID42611994
PMCPMC13506043
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