Evidence map›Paper›PMID 42614372›Full record

ArticleMolecular therapy. Advances2026

i.c.v. delivery of AAV9-synapsin-promoted caveolin-1 attenuates neuromuscular deficits and neuromuscular degeneration in hSOD1

Noriyuki Watanabe, Yumi Kawahori, Vinh Ta, Dongsheng Wang, Kenneth A Ohgi, Hongxia Wang, Natalia Kleschevnikova, Eiichi Ishikawa, Brian P Head

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Noriyuki WatanabeDepartment of Anesthesiology, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA 92093, USA.
Yumi KawahoriDepartment of Anesthesiology, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA 92093, USA.
Vinh TaDepartment of Anesthesiology, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA 92093, USA.
Dongsheng WangDepartment of Anesthesiology, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA 92093, USA.
Kenneth A OhgiDepartment of Anesthesiology, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA 92093, USA.
Hongxia WangDepartment of Anesthesiology, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA 92093, USA.
Natalia KleschevnikovaDepartment of Anesthesiology, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA 92093, USA.
Eiichi IshikawaDepartment of Neurosurgery, Institute of Medicine, University of Tsukuba, 1-1-1- Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Brian P HeadDepartment of Anesthesiology, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA 92093, USA.

Funding

BLRD VA IK6 BX006318
6 · The paper itself

Abstract

Practical and broad biodistributable gene delivery interventions are essential for advancing therapeutic strategies targeting neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). We previously demonstrated that subpial delivery of AAV9-synapsin-promoted caveolin-1 (

Indexed as

AAV9-SynCav1amyotrophic lateral sclerosiscaveolin-1intracerebroventricular administrationmotor neuronneuroprotection

Identifiers

PMID42614372
PMCPMC13481751

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.