SynthesisFrontiers in neuroscience2026
Effects of acupuncture on mild cognitive impairment via the microbiota-gut-brain axis: a systematic review.
Synthesis in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Mild Cognitive Impairment (MCI) is a critical window for intervention in neurodegenerative diseases. As emerging evidence suggests the role of microbiota-gut-brain (MGB) axis on cognitive health, this systematic review aims to evaluate the efficacy and underlying mechanisms of acupuncture in modulating the MGB axis to alleviate cognitive decline. Methods: A systematic search was conducted across PubMed/MEDLINE, Web of Science, Scopus, and Cochrane CENTRAL from inception to April 2026. Following PRISMA 2020 guidelines, we included both clinical randomized controlled trials (RCTs) and preclinical animal studies investigating acupuncture's effects on MCI via gut microbiota. Results: Five studies (2 clinical randomized controlled trials, Conclusion: Acupuncture alleviates MCI by modulating the MGB axis, enriching beneficial microbiota to restore intestinal integrity and suppress neuroinflammation. These microbial shifts correlate with improved functional connectivity, establishing acupuncture as a potent gut-centric neuroprotective strategy for cognitive health.
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