ReviewFrontiers in pharmacology2026
Rewiring immunity in rheumatoid arthritis: metabolic and epigenetic therapeutic strategies.
Review in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Rheumatoid arthritis (RA) is a systemic autoimmune disease marked by chronic inflammation and destruction of joints and surrounding soft tissues. The pathogenesis of RA is heavily driven by two intertwined and mutually regulatory processes: metabolic reprogramming and epigenetic remodeling. Recent advances reveal a crucial crosstalk wherein metabolic intermediates derived from immune cells act as substrates or cofactors for chromatin-modifying enzymes. This interplay profoundly shapes epigenetic landscapes, thereby exacerbating inflammatory responses and disease progression. Here, we review the mechanisms underlying immune cell metabolic reprogramming in RA and critically examine how metabolite-mediated epigenetic remodeling orchestrates disease pathology. Furthermore, we summarize state-of-the-art epigenetic-targeted therapeutic strategies, offering new insights and a solid theoretical basis for treating RA through the metabolic-epigenetic axis.
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