ArticleInfection and drug resistance2026
Lineage-Dependent IFN-γ Responses to Drug-Sensitive and Isoniazid-Resistant
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Genetic diversity of Methods: Peripheral blood mononuclear cells (PBMCs) from 18 healthy adults were stimulated with lysates of clinical Results: MB isolates induced significantly lower IFN-γ levels than LAM isolates (15.30 ± 6.28 vs 19.16 ± 7.28 pg/mL; p < 0.001). Similarly, Hr-TB isolates induced lower IFN-γ responses than DS isolates (15.44 ± 6.39 pg/mL vs 19.02 ± 7.26 pg/mL; p < 0.001). Stratified analysis revealed that within the MB lineage, Hr-TB isolates significantly reduced IFN-γ production compared to DS isolates (13.14 ± 6.13 pg/mL vs 17.45 ± 5.81 pg/mL; p < 0.001). In contrast, no significant difference was observed between DS and Hr-TB isolates within the LAM lineage (p = 0.061). No significant interaction was observed between Conclusion: These findings demonstrate that IFN-γ responses to
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