ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Regional amyloid accumulation, post-traumatic distress, and intrusive symptoms in cognitively unimpaired older adults at risk for Alzheimer's.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
introductionIn preclinical Alzheimer's disease (AD), early pathology may heighten vulnerability to psychiatric symptoms. We examined whether Aβ accumulation in cognitive-emotional regions was associated with post-pandemic psychiatric symptoms.
methodsThis prospective cohort study included 115 cognitively unimpaired ALzheimer's and FAmilies participants (69 [60%] women, mean [SD] age 64.9 [4.8] years). Amyloid beta (Aβ) change was examined in anterior cingulate, posterior cingulate, superior parietal, medial orbitofrontal gyri, and insula using two [18F]flutemetamol positron emission tomography (PET) scans. Outcomes were pandemic-related post-traumatic distress (Impact of Events Scale Revised [IES-R]; total, intrusive, avoidance, and hyperarousal symptoms) and anxious-depressive symptoms (Hospital Anxiety and Depression Scale [HADS]; mean follow-up: 3.62 years [SD = 0.68]). Linear regression and voxel-wise analyses were performed.
resultsAβ accumulation across anterior cingulate ( DISCUSSION: Aβ accumulation in cognitive-emotional regions may increase vulnerability to intrusive symptoms, highlighting their potential as early clinical markers in AD.
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