Evidence map›Paper›PMID 42615437›Full record

ReviewJACC. Asia2026

South Asian Cardiovascular Risk: Role of Coronary Artery Calcium Scoring and Computed Tomography Angiography.

Dinesh K Kalra, Deepak Vedamurthy, Nisha Hosadurg, Abhinav Goyal, Milan Gupta, Neha Pagidipati, Leandro Slipczuk, Damini Dey, Anurag Mehta, Parag Joshi and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in JACC. Asia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dinesh K KalraDivision of Cardiology, University of Louisville, Louisville, Kentucky, USA. Electronic address: dinesh.kalra@louisville.edu.
Deepak VedamurthyDivision of Cardiology, University of Louisville, Louisville, Kentucky, USA.
Nisha HosadurgDivision of Cardiology, University of Virginia, Charlottesville, Virginia, USA.
Abhinav GoyalDivision of Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA.
Milan GuptaDepartment of Medicine, University of Toronto, Toronto, Ontario, Canada.
Neha PagidipatiDivision of Cardiology, Duke University School of Medicine, Durham, North Carolina, USA.
Leandro SlipczukCardiology Division, Montefiore Health System/Albert Einstein College of Medicine, New York, New York, USA.
Damini DeyDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Anurag MehtaDivision of Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA.
Parag JoshiDivision of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Lohendran BaskaranDepartment of Cardiology, National Heart Centre, Singapore, Singapore.
Nathan WongDivision of Cardiology, University of California-Irvine, Irvine, California, USA.
Salim S ViraniDepartment of Medicine, Aga Khan University, Karachi, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

South Asians (SAs) experience a disproportionately high burden of premature atherosclerotic cardiovascular disease, yet conventional risk assessment algorithms often underestimate their cardiovascular risk. This review highlights the evolving role of atherosclerosis imaging, namely, coronary artery calcium scoring and coronary computed tomographic angiography (CTA), as complementary tools for earlier detection and refined risk stratification in SAs. The authors review evidence demonstrating earlier appearance and greater coronary plaque burden in SAs, often accompanied by higher risk plaque features and inflammation, even in the setting of a zero or low coronary artery calcium score. Advances in coronary CTA, including artificial intelligence-enabled plaque quantification, perivascular fat attenuation index, and computed tomography-derived fractional flow reserve, enable the characterization of high-risk vascular biology and may guide targeted preventive therapies. Coronary artery calcium scoring can refine risk in SAs as broadly as in other ethnic groups. However, in younger SAs who may not yet have developed calcified plaque, the selective and judicious application of coronary CTA to visualize noncalcified plaque in targeted high-risk individuals offers an evolving strategy for earlier and personalized initiation of aggressive preventive therapies.

Indexed as

atherosclerosispreventionrisk assessment

Identifiers

PMID42615437
PMCPMC13491094

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.