ArticleProteomics. Clinical applications2026
Differential Expression of Human and Bacterial Proteins Reveals Microbiome-Host Crosstalk in Metabolic Disorders.
Article in Proteomics. Clinical applications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThe growing prevalence of obesity, MetS, and T2DM highlights the need to better understand host-microbiota interactions. While gut microbiota has been widely investigated, interactions between the oral microbiota and human salivary proteins remain largely unexplored. EXPERIMENTAL
designThis study investigated the integrated human salivary proteome and bacterial secreted metaproteome in Brazilian individuals spanning different metabolic states: normal weight/control, overweight, obesity, MetS, and T2DM. Saliva samples were analyzed using mass spectrometry-based proteomics to identify differential protein profiles.
resultsKey findings revealed significant downregulation of human proteins MYSM1 (eta2 = 0.710, 95% CI: [0.642, 0.825], qadj< 0.001) and GAD65 (η CONCLUSIONS AND CLINICAL RELEVANCE: These findings underscore the pivotal role of host-microbiota interactions in the oral cavity during the pathogenesis of obesity, MetS, and T2DM, highlighting the importance of further elucidating the molecular and functional mechanisms underlying microbiota-host crosstalk in metabolic diseases.
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