Evidence map›Paper›PMID 42615769›Full record

GuidelineArquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery2026

Prevention, surveillance, and early detection of hepatocellular carcinoma - a Brazilian multidisciplinary consensus.

Felipe José Fernández Coimbra, André Luís de Godoy, Paulo Henrique de Sousa Fernandes, Heládio Feitosa E Castro Neto, Rodrigo Nascimento Pinheiro, Ilka de Fátima Santana Ferreira Boin, Wellington Andraus, Francisco Tustumi, Paulo Cezar Galvão do Amaral, Carlos Eduardo Brandão-Mello and 33 more

Abstract readConsensus StatementPractice GuidelineReview
In one paragraph

Guideline in Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Diagnosis, clinical assessment, and staging of hepatocellular carcinoma: a Brazilian multidisciplinary consensus.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors.

Felipe José Fernández CoimbraA.C. Camargo Cancer Center, Department of Surgical Oncology, Abdominal Surgery - São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0001-5068-0639
André Luís de GodoyA.C. Camargo Cancer Center, Department of Surgical Oncology, Abdominal Surgery - São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0002-7154-1184
Paulo Henrique de Sousa FernandesUniversidade Federal de Uberlândia, Department of Surgical Oncology - Uberlândia (MG), Brazil.ORCID http://orcid.org/0000-0001-5476-2017
Heládio Feitosa E Castro NetoInstituto do Câncer do Ceará, Department of Surgical Oncology - Fortaleza (CE), Brazil.ORCID http://orcid.org/0000-0001-6455-916X
Rodrigo Nascimento PinheiroHospital de Base do Distrito Federal, Department of Surgical Oncology - Brasília (DF), Brazil.ORCID http://orcid.org/0000-0002-2715-7628
Ilka de Fátima Santana Ferreira BoinUniversidade Estadual de Campinas, Department of Surgery and Gastrocenter - Campinas (SP), Brazil.ORCID http://orcid.org/0000-0002-1165-2149
Wellington AndrausUniversidade de São Paulo, Department of Gastroenterology - São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0002-5162-138X
Francisco TustumiUniversidade de São Paulo, Department of Gastroenterology - São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0001-6695-0496
Paulo Cezar Galvão do AmaralSão Rafael Hospital/Hospital Rede D'Or, Department of Surgery of the Upper Digestive System - Salvador (BA), Brazil.ORCID http://orcid.org/0000-0002-2510-0193
Carlos Eduardo Brandão-MelloUniversidade Federal do Estado do Rio de Janeiro, Department of Internal Medicine - Rio de Janeiro (RJ), Brazil.ORCID http://orcid.org/0000-0001-8965-6556
Alexcia Camila BraunA.C. Camargo Cancer Center, Department of Surgical Oncology, Abdominal Surgery - São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0002-9028-2026
Maria Ignez BraghiroliInstituto do Câncer do Estado de São Paulo, Department of Oncology - São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0001-6366-8786
Luis César BredtUniversidade Estadual do Oeste do Paraná, Department of Surgical Oncology and Hepatobilary Surgery - Cascavel (PR), Brazil.ORCID http://orcid.org/0000-0002-8587-1790
Carla CaparrozHospital Beneficência Portuguesa de São Paulo, Department of Radiology - São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0002-0628-2016
Flair José CarrilhoUniversidade de São Paulo, Department of Gastroenterology - São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0002-7682-3105
Guilherme Moura CunhaUniversity of Washington, Department of Radiology - Seattle, USA.ORCID http://orcid.org/0000-0001-6403-5155
Alessandro Landskron DinizA.C. Camargo Cancer Center, Department of Surgical Oncology, Abdominal Surgery - São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0001-9671-2026
Daniel Neves ForteUniversidade de São Paulo, Emergency Department - São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0003-1996-7193
José Huygens Parente GarciaUniversidade Federal do Ceará, Hospital Universitário Walter Cantídio, Department of Surgery, Liver Transplant Unit - Fortaleza (CE), Brazil.ORCID http://orcid.org/0000-0002-5057-7903
Tércio GenziniHospital Leforte, Pancreas and Kidney Transplant Program - São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0002-3589-3983
Mauro Monteiro CorreiaInstituto Nacional de Câncer, Department of Abdominopelvic Surgery - Rio de Janeiro (RJ), Brazil.ORCID http://orcid.org/0009-0005-4365-6899
Cássio Virgílio Cavalcante de OliveiraUniversidade Federal da Paraíba, Department of Surgery - João Pessoa (PB), Brazil.ORCID http://orcid.org/0000-0001-8385-7656
Antonio Nocchi KalilIrmandade Santa Casa de Misericórdia de Porto Alegre, Department of Hepato-Biliary-Pancreatic Surgery and Liver Transplantation - Porto Alegre (RS), Brazil.ORCID http://orcid.org/0000-0002-2658-0731
Agnaldo Soares LimaUniversidade Federal de Minas Gerais, Department of Surgery - Belo Horizonte (MG), Brazil.ORCID http://orcid.org/0000-0001-6421-3062
Guilherme Lopes Pinheiro MartinsInstituto do Câncer do Estado de São Paulo, Radiology Department - São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0002-2617-2316
Cristina Melo RochaUniversidade Federal do Amazonas, Department of Gastroenterology - Manaus (MN), Brazil.ORCID http://orcid.org/0000-0002-3772-362X
Marcos Roberto de MenezesUniversidade de São Paulo, Department of Radiology - São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0001-7548-8774
Joaquim Maurício da Motta-Leal-FilhoUniversidade de São Paulo, Department of Radiology - São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0001-9844-6833
Munir Murad JúniorUniversidade Federal de Minas Gerais, Department of Oncology - Belo Horizonte (MG), Brazil.ORCID http://orcid.org/0009-0002-1791-8814
Renata D'Alpino PeixotoUniversity of British Columbia, Department of Medical Oncology - Vancouver, Canada.ORCID http://orcid.org/0000-0003-0053-7951
Rafael Soares Nunes PinheiroUniversidade de São Paulo, Department of Gastroenterology - São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0001-8632-3529
Marcelo Bruno de RezendeHospital Israelita Albert Einstein, Department of Health Sciences - São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0001-5594-033X
Héber Salvador de Castro RibeiroA.C. Camargo Cancer Center, Department of Surgical Oncology, Abdominal Surgery - São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0002-3412-7451
Mario Rino MartinsHospital de Câncer de Pernambuco, Department of Oncological Surgery - Recife (PE), Brazil.ORCID http://orcid.org/0000-0001-8705-8210
Duilio Reis da Rocha FilhoUniversidade Federal do Ceará, Department of Oncology - Fortaleza (CE), Brazil.ORCID http://orcid.org/0000-0001-7756-1891
Arthur Accioly RosaHospital Santa Izabel and Oncoclínicas, Department of Radiation Oncology - Salvador (BA), Brazil.ORCID http://orcid.org/0000-0002-6958-832X
Luiz Arnaldo SzutanSanta Casa de São Paulo, Faculdade de Ciências Médicas, Department of Surgery - São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0002-1529-0579
Orlando Jorge Martins TorresUniversidade Federal do Maranhão, Department of Gastrointestinal Surgery - São Luis (MA), Brazil.ORCID http://orcid.org/0000-0002-7398-5395
Luiz Augusto Carneiro D'AlbuquerqueUniversidade de São Paulo, Department of Gastroenterology - São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0001-7607-7168
Ângelo Alves de MattosUniversidade Federal de Ciências da Saúde de Porto Alegre, Department of Gastroenterology and Hepatology - Porto Alegre (RS), Brazil.ORCID http://orcid.org/0000-0003-2417-9765
Anelisa Kruschewsky CoutinhoRede Mater Dei, Department of Oncology - Salvador (BA), Brazil.ORCID http://orcid.org/0000-0003-2988-0446
Paulo HermanUniversidade de São Paulo, Department of Gastroenterology - São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0003-2859-5846
Alexandre Ferreira OliveiraUniversidade Federal de Juiz de Fora, Department of Surgery - Juiz de Fora (MG), Brazil.ORCID http://orcid.org/0000-0002-7500-6752

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatocellular carcinoma is a major cause of cancer-related mortality and represents a growing public health challenge.

aimsTo develop multidisciplinary evidence-based recommendations for the prevention and early detection of hepatocellular carcinoma.

methodsThis consensus was coordinated by the Brazilian Society of Surgical Oncology, with the participation of 13 additional national societies. A steering committee defined the key clinical questions addressing prevention, surveillance, and early detection strategies. Recommendation statements were informed by a comprehensive, non-systematic review of the literature conducted using PubMed, Scopus, and the Cochrane Library.

resultsEighteen recommendations reached consensus, covering three main domains: 1. Primary prevention, including HBV vaccination, timely antiviral therapy for viral hepatitis, and lifestyle interventions for metabolic dysfunction. 2. Secondary prevention, outlining risk-based surveillance strategies for patients with advanced fibrosis or cirrhosis due to hepatitis B virus, hepatitis C virus, or metabolic dysfunction-associated steatotic liver disease. 3. Operational standards for surveillance, emphasizing ultrasound as the cornerstone of monitoring, the importance of structured reporting, management of small nodules, and the selective use of cross-sectional imaging.

conclusionsThese multidisciplinary recommendations provide practical, adaptable guidance for the prevention, surveillance, and early detection of hepatocellular carcinoma. This guidance document aims to reduce the burden of hepatocellular carcinoma and support better clinical outcomes across diverse healthcare settings. CENTRAL MESSAGE: Prevention and early detection save lives in liver cancer. This Brazilian multidisciplinary consensus integrates the best scientific evidence and the expertise of specialists from across the country to more effectively guide the prevention, identification, and surveillance of hepatocellular carcinoma. By answering key clinical questions and offering practical, easy-to-use recommendations, this document helps physicians and healthcare teams provide better care to people at risk. PERSPECTIVES: This consensus provides practical guidance to improve the prevention and early detection of liver cancer in daily clinical care. The recommendations emphasize raising awareness of hepatocellular carcinoma, stimulating the development of broader surveillance programs, promoting earlier diagnosis, and improving outcomes for patients at risk for developing primary liver cancer.

Indexed as

Carcinoma, HepatocellularEarly Detection of CancerLiver NeoplasmsBrazilHumans

Identifiers

PMID42615769
PMCPMC13488426

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.