ArticleInvestigative ophthalmology & visual science2026
In Vivo Human Cone Photoreceptor Inner Segment Diameter Database Using Adaptive Optics Retinal Imaging.
Article in Investigative ophthalmology & visual science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The trial behind it
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Who cites it
2 citing papers in PubMed.
- In vivo adaptive optics retinal imaging reveals rod-mediated cone photoreceptor disorganization in RHO-associated retinitis pigmentosa.npj biomedical innovations · 2026Article
- Open-Source Software Suite for Cell Detection and Segmentation in Adaptive Optics Retinal Imaging.Translational vision science & technology · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Purpose: To establish an in vivo database of human cone photoreceptor inner segment diameter evaluated across the lifespan. Methods: Non-confocal split detection adaptive optics (AO) imaging was performed in 28 eyes of 28 healthy subjects (14 females and 14 males; 45.1 ± 20.7 years, ranging from 12-84 years). Cone photoreceptor inner segments were semi-automatically segmented and cone diameters measured from the AO images across eccentricities ranging from 1.0 to 6.0 mm temporal to the fovea. A linear mixed-effects model was used to assess the relationship between cone diameter and sex as well as cone diameter and age. Results: Cone photoreceptor inner segment diameter increased with increasing eccentricity (n = 9350 segmented cones), from an average of 5.0 µm (eccentricity: 1.0 mm) to 7.8 µm (6.0 mm). Overall, cone diameter in females was slightly greater (by an average of 5%) than cone diameter in males across most eccentricities measured. The differences in cone diameter between females and males could not be accounted for by differences in axial length or age. In addition, cone diameters in younger subjects were generally larger than those from older subjects. Conclusions: In vivo measurements of human cone photoreceptor inner segment diameter across the lifespan are necessary for future comparisons with data from age-related disease. Statistically significant differences due to both age and sex were observed.
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Registered trials
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